Death related to consumption of Rauvolfia sp powder mislabeled as Tabernanthe iboga
Death related to consumption of Rauvolfia sp powder mislabeled as Tabernanthe iboga
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DOI：
10.1016/j.forsciint.2016.06.014
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发表时间：
2016-09-01
影响因子：
2.2
通讯作者：
Morel, Isabelle
中科院分区：
文献类型：
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作者：
Gicquel, Thomas;Hugbart, Chloe;Morel, Isabelle
iboga（Tabernanthe iboga）的粉末状根含有ibobalone，一种用于治疗成瘾的生物碱。我们报告的情况下，一名30岁的妇女谁后ingredia粉末标记为Tabernanthe iboga她在网上购买的死亡。对粉末的分析显示，不含伊博格因，但存在萝芙木属植物物种中发现的有毒生物碱（阿义马林、育亨宾和利血平）。开发的用于定量阿曲匹林、育亨宾和利血平的原始和特异性LC-MS/MS方法显示，血液中的浓度分别为109.1 ng/mL、98.2 ng/mL和30.8 ng/mL，胆汁中的浓度分别为1528.2 ng/mL、914.2 ng/mL和561.2 ng/mL。此外，对生物样本的系统毒理学分析表明，存在治疗浓度的奥沙西泮和大麻素。死亡可归因于摄入大量萝芙木根粉碎物，伴随药物停药。(C)2016爱思唯尔爱尔兰有限公司版权所有。
Powdered roots of iboga (Tabernanthe iboga) contain ibogaine, an alkaloid that has been used to treat addictions. We report the case of a 30-year-old woman who died after ingesting a powder labeled as Tabernanthe iboga she had bought online. Analysis of the powder revealed the absence of ibogaine but the presence of toxic alkaloids (ajmaline, yohimbine and reserpine) found in Rauvolfia sp. plant species. An original and specific LC-MS/MS method developed to quantify ajmaline, yohimbine and reserpine showed respective concentrations of 109.1 ng/mL, 98.2 ng/mL and 30.8 ng/mL in blood, and 1528.2 ng/mL, 914.2 ng/mL and 561.2 ng/mL in bile. Moreover, systematic toxicological analyses of biological samples showed the presence of oxazepam at therapeutic concentration and cannabinoids. Death could be attributed to ingestion of a substantial quantity of crushed roots of Rauvolfia in association with concomitant drug withdrawal. (C) 2016 Elsevier Ireland Ltd. All rights reserved.