Impact of HMG-CoA reductase inhibitors on the incidence of polyomavirus-associated nephropathy in renal transplant recipients with human BK polyomavirus viremia.
Impact of HMG-CoA reductase inhibitors on the incidence of polyomavirus-associated nephropathy in renal transplant recipients with human BK polyomavirus viremia.
复制标题
HMG-CoA 还原酶抑制剂对患有人 BK 多瘤病毒血症的肾移植受者多瘤病毒相关肾病发病率的影响。
DOI：
10.1111/tid.12402
复制
发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Tan,CS
中科院分区：
文献类型：
--
作者：
Gabardi,S;Ramasamy,S;Kim,M;Klasek,R;Carter,D;Mackenzie,MR;Chandraker,A;Tan,CS
BackgroundUp to 20% of renal transplant recipients (RTR) will develop human BK polyomavirus (BKPyV) viremia. BKPyV viremia is a pre‐requisite of polyomavirus‐associated nephropathy (PyVAN). Risk of BKPyV infections increases with immunosuppression. Currently, the only effective therapy against PyVAN is reductions in immunosuppression, but this may increase the risk of rejection.In vitrodata have shown that pravastatin dramatically decreased caveolin‐1 expression in human renal proximal tubular epithelial cells (HRPTEC) and suppressed BKPyV infection in these cells. Based on these data, we postulated that statin therapy may prevent the progression of BKPyV viremia to PyVAN.Patients and methodsA multicenter, retrospective study was conducted in adult RTR transplanted between July 2005 and March 2012. All patients with documented BKPyV viremia (viral load >500 copies/mL on 2 consecutive tests) were included. Group I consisted of patients taking a statin before the BKPyV viremia diagnosis (n= 32), and Group II had no statin exposure before or after the BKPyV viremia diagnosis (n= 36). The primary endpoint was the incidence of PyVAN.ResultsDemographic data, transplant characteristics, and the degree of immunosuppression (i.e., induction/maintenance therapies, rejection treatment) were similar between the groups, with the exception of more diabetics in Group I. The incidence of PyVAN was comparable between the 2 groups (Group I = 28.1% vs. Group II = 41.7%;P= 0.312).ConclusionsDespite the provenin vitroeffectiveness of pravastatin preventing BKPyV infection in HRPTEC, statins at doses maximized for cholesterol lowering, in RTR with BKPyV viremia, did not prevent progression to PyVAN.
