Rules ventral prefrontal cortical axons use to reach their targets: implications for diffusion tensor imaging tractography and deep brain stimulation for psychiatric illness.
Rules ventral prefrontal cortical axons use to reach their targets: implications for diffusion tensor imaging tractography and deep brain stimulation for psychiatric illness.
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DOI：
10.1523/jneurosci.0595-11.2011
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发表时间：
2011-07-13
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影响因子：
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通讯作者：
Haber SN
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作者：
Lehman JF;Greenberg BD;McIntyre CC;Rasmussen SA;Haber SN
腹侧前额叶皮质(VPFC)参与基于强化的学习，并与抑郁、强迫症和成瘾有关。神经成像越来越多地被用于开发vPFC连接的模型，检查白质(WM)的完整性，并针对手术干预，包括脑深部刺激。我们使用灵长类(猕猴/束猕猴)追踪研究和WM束的3D重建来描绘vPFC投射到达目标所遵循的规则。VPFC传出轴突穿过钩状束，连接不同的vPFC区域，连接不同的功能区。钩状束也是vPFC纤维到达其他皮质束的管道。根据目的地组织内囊中的纤维。来自每个vPFC区域的丘脑纤维背向其脑干纤维。结果表明，来自不同vPFC区域的纤维的轨迹存在区域差异。总体而言，vPFC的内侧/外侧位置决定了纤维进入主要的WM束的路径，以及特定束内的位置：来自内侧vPFC区域的轴突通过腹侧到达来自更外侧区域的轴突。这种排列，再加上丘脑/脑干纤维通过内囊的背侧/腹侧组织，导致来自不同vPFC区域的丘脑和脑干轴突的复杂混合。总而言之，这些数据为将vPFC WM捆绑包划分为功能组件以及预测每个捆绑包在不同点可能承载的内容提供了基础。这些结果也有助于确定在不同的神经外科目标上可能捕捉到的特定联系。
The ventral prefrontal cortex (vPFC) is involved in reinforcement-based learning and is associated with depression, obsessive-compulsive disorder, and addiction. Neuroimaging is increasingly used to develop models of vPFC connections, to examine white matter (WM) integrity, and to target surgical interventions, including deep brain stimulation. We used primate (Macaca nemestrina/Macaca fascicularis) tracing studies and 3D reconstructions of WM tracts to delineate the rules vPFC projections follow to reach their targets. vPFC efferent axons travel through the uncinate fasciculus, connecting different vPFC regions and linking different functional regions. The uncinate fasciculus also is a conduit for vPFC fibers to reach other cortical bundles. Fibers in the internal capsule are organized according to destination. Thalamic fibers from each vPFC region travel dorsal to their brainstem fibers. The results show regional differences in the trajectories of fibers from different vPFC areas. Overall, the medial/lateral vPFC position dictates the route that fibers take to enter major WM tracts, as well as the position within specific tracts: axons from medial vPFC regions travel ventral to those from more lateral areas. This arrangement, coupled with dorsal/ventral organization of thalamic/brainstem fibers through the internal capsule, results in a complex mingling of thalamic and brainstem axons from different vPFC areas. Together, these data provide the foundation for dividing vPFC WM bundles into functional components and for predicting what is likely to be carried at different points through each bundle. These results also help determine the specific connections that are likely to be captured at different neurosurgical targets.