Genetic relationship of Chinese ethnic populations revealed by mtDNA sequence diversity.
Genetic relationship of Chinese ethnic populations revealed by mtDNA sequence diversity.
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DOI：
10.1002/ajpa.10052
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发表时间：
2002-05
影响因子：
2.8
通讯作者：
Yong-Gang Yao;L. Nie;Henry Harpending;Yun-Xin Fu;Zhi-gang Yuan;Ya-ping Zhang
中科院分区：
文献类型：
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作者：
Yong-Gang Yao;L. Nie;Henry Harpending;Yun-Xin Fu;Zhi-gang Yuan;Ya-ping Zhang
中国各民族的起源和人口历史尚未明确解决。在这项研究中，我们检查了来自 9 个中国人群和 1 个泰国北部人群的 372 名个体线粒体 DNA 控制区的高变片段 I 序列 (HVSI)。发现相对较高比例的个体与来自同一种族发生的其他群体的个体共享序列。总体而言，与北方或氐羌部落起源的种群相比，南方或排越部落起源的种群表现出较高的单倍型多样性和核苷酸多样性。这些人群的不匹配分布表现出一致的特征。除北方族群怒族、傈僳族、藏族和蒙古族外，所有族群在错配分布和中性检验中都表现出古代人口扩张的典型特征。过去发生的物种数量极度减少的事件可能是北方种群缺乏扩张证据的可能解释之一。小样本量以及来自孤立亚群的样本导致了观察到的凹凸不平的失配分布。系统发育分析和人群之间的单倍型共享表明，这些民族目前的线粒体DNA变异可以在一定程度上揭示其民族史，但总体而言，这些民族的语言和地理分类与线粒体DNA变异的分类并不一致。
The origin and demographic history of the ethnic populations of China have not been clearly resolved. In this study, we examined the hypervariable segment I sequences (HVSI) of the mitochondrial DNA control region in 372 individuals from nine Chinese populations and one northern Thai population. A relatively high percentage of individuals was found to share sequences with those from other populations of the same ethnogenesis. In general, the populations of southern or Pai-Yuei tribal origin showed high haplotype diversity and nucleotide diversity compared with the populations of northern or Di-Qiang tribal origin. Mismatch distributions from these populations showed concordant features. All except the northern groups Nu, Lisu, Tibetan, and Mongolian showed typical signatures of ancient population expansions in the mismatch distributions and neutrality tests. Episodes of extreme size reduction in the past are one of the likely explanations for the absence of evidence of expansion in northern populations. Small sample sizes as well as samples from isolated subpopulations contributed to the bumpy mismatch distributions observed. Phylogenetic analysis and haplotype sharing among populations suggest that current mtDNA variation in these ethnic populations could reveal their ethnohistory to some extent, but in general, linguistic and geographic classifications of the populations did not agree well with classification by mtDNA variation.