Enzyme Studies in Tardive Dyskinesia. III. Noradrenergic Hyperactivity in a Subgroup of Dyskinetic Patients
Enzyme Studies in Tardive Dyskinesia. III. Noradrenergic Hyperactivity in a Subgroup of Dyskinetic Patients
复制标题
迟发性运动障碍的酶研究。
DOI：
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发表时间：
1982
影响因子：
2.9
通讯作者：
R. Wyatt
中科院分区：
文献类型：
--
作者：
D. Jeste;M. Linnoila;C. Fordis;B. Phelps;R. Wagner;R. Wyatt
This study was undertaken to test a hypothesis that tardive dyskinesia (TD) patients with high plasma dopamine-β-hydroxylase (DBH) activity would also have other enzymatic alterations suggestive of noradrenergic hyperactivity. Plasma renin activity was chosen as a peripheral indicator of noradrenergic function. We measured plasma renin activity in three groups of female psychiatric inpatients over the age of 50: a TD group with high plasma DBH activity, a TD group with low plasma DBH activity, and a non-TD group. The high-DBH TD group had significantly greater plasma renin activity than the other two groups. Our results are consistent with the hypothesis that a subgroup of TD patients has relative noradrenergic hyperactivity.
