Low levels of inflammation and the absence of subclinical atherosclerosis in rheumatoid arthritis
Low levels of inflammation and the absence of subclinical atherosclerosis in rheumatoid arthritis
复制标题
DOI：
10.3892/mmr.2016.4962
复制
发表时间：
2016-04-01
影响因子：
3.4
通讯作者：
Libra, Massimo
中科院分区：
文献类型：
--
作者：
Signorelli, Salvatore Santo;Candido, Saverio;Libra, Massimo
类风湿关节炎是一种慢性自身免疫性炎症性疾病。类风湿性关节炎患者发生心血管疾病的风险增加，但其动脉并发症的病理生理机制仍未完全阐明。了解血管损伤的早期标志可能有助于预防类风湿关节炎患者的心血管并发症。目前的研究招募了30名RA患者和30名健康受试者对此进行了调查。动脉内膜-中层厚度(IMT)用于检测动脉粥样硬化性疾病的存在，并测量颈动脉和股动脉。检测肿瘤坏死因子α、白介素6、白介素8、白介素10和基质金属蛋白酶2作为炎症标志物。30例RA患者中有7例IMT&Gt；=0.9 mm，但在炎症标志物分析中，RA患者与对照组之间无显著差异。值得注意的是，这些结果表明，RA的适当治疗可能影响了这些患者的炎症状态，从而可能对亚临床动脉粥样硬化产生了影响。
Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disease. Patients with RA have an increased risk for the development of cardiovascular diseases, however, the pathophysiological mechanisms of arterial complications in RA remain to be fully elucidated. Understanding the early markers of vascular damage may aid in preventing cardiovascular complications in patients with RA. The current study investigated this by recruiting 30 patients with RA and 30 healthy subjects. Intima-media thickness (IMT) was used to detect the presence of atherosclerotic disease and was measured in the carotid and femoral arteries. Tumor necrosis factor alpha, interleukin-6 (IL-6), IL-8, IL-10 and matrix metalloproteinase-2 were measured as markers of inflammation. An IMT >= 0.9 mm was observed in 7/30 patients with RA, however, no significant differences between patients with RA and the controls were observed in the inflammatory markers analyzed. Of note, these results indicated that the appropriate management of RA may have affected the inflammatory status of these patients and consequently may have impacted upon subclinical atherosclerosis.