Semaphorin3A promotes osseointegration of titanium implants in osteoporotic rabbits
Semaphorin3A promotes osseointegration of titanium implants in osteoporotic rabbits
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Semaphorin3A 促进骨质疏松兔钛种植体的骨整合
DOI：
10.1007/s00784-021-04081-6
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发表时间：
2021-08
影响因子：
3.4
通讯作者：
Zhou Junbo
中科院分区：
文献类型：
--
作者：
Song An;Jiang Feng;Wang Yi;Wang Ming;Wu Yanhui;Zheng Yang;Song Xiaomeng;Zhang Wei;Zhou Junbo
ObjectiveIn the present study, we intend to assess the function of Sema3A in osteointegration of titanium implants bothin vivoandin vitro.Material and methodsBriefly, Sema3A was transfected in HBMSCs cells to detect its effect on osteogenesis. Subsequently, an in vivo rabbit model was established. Eighteen female rabbits were randomly assigned into three groups (n=6), and rabbits in the two treatment groups (OVX groups) were subjected to bilateral ovariectomy, while those in the control group were treated with sham operation. Twelve weeks later, we first examined expression levels of Sema3A in rabbits of the three groups. Titanium implants were implanted in rabbit proximal tibia. Specifically, rabbits in sham group were implanted with Matrigel, while the remaining in the OVX experimental group (OVX+Sema3A group) and OVX group were implanted with Matrigel containing Sema3A adeno-associated virus or empty vector, respectively.ResultsHistomorphometry results uncovered that rabbits in the OVX+Sema3A group had a significantly higher BIC compared with those of the OVX group on the 12th week of post-implantation. And compared with the OVX group, the maximum push-out force increased by 89.4%, and the stiffness increased by 39.4%, the toughness increased by 63.8% in the OVX+Sema3A group at 12 weeks.ConclusionSema3A has a positive effect on promoting early osseointegration of titanium implants in osteoporotic rabbits.Clinical relevanceOur research found that Sema3A can improve the osteogenic ability of bone marrow stem cells and promotes osseointegration during osteoporosis.
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影响因子：
5.9
作者：
Suzuki T;Nakamura Y;Kato H
通讯作者：
Kato H
使用飞秒激光消融从蛋壳中从蛋壳中合成三维碳酸钙纳米纤维结构。
影响因子：
10.2
作者：
Tavangar A;Tan B;Venkatakrishnan K
通讯作者：
Venkatakrishnan K
影响因子：
--
作者：
Rachmiel A;Shilo D
通讯作者：
Shilo D
影响因子：
9.8
作者：
Giacobini P;Parkash J;Campagne C;Messina A;Casoni F;Vanacker C;Langlet F;Hobo B;Cagnoni G;Gallet S;Hanchate NK;Mazur D;Taniguchi M;Mazzone M;Verhaagen J;Ciofi P;Bouret SG;Tamagnone L;Prevot V
通讯作者：
Prevot V
影响因子：
2.9
作者：
Moro-Alvarez, M. J.;Blazquez Cabrera, J. A.
通讯作者：
Blazquez Cabrera, J. A.