ARGINYL-GLYCYL-ASPARTIC ACID (RGD) - A CELL-ADHESION MOTIF
ARGINYL-GLYCYL-ASPARTIC ACID (RGD) - A CELL-ADHESION MOTIF
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DOI：
10.1016/0968-0004(91)90096-e
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发表时间：
1991-07-01
影响因子：
13.8
通讯作者：
PLOW, EF
中科院分区：
文献类型：
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作者：
DSOUZA, SE;GINSBERG, MH;PLOW, EF
精氨酸-甘氨酸-天冬氨酸(Arg-Gly-Asp，RGD)三肽最初被鉴定为纤维连接蛋白中介导细胞附着的序列。RGD基序现在已经在许多其他蛋白质中被发现，并在许多但不是所有这些蛋白质中支持细胞黏附。整合素是一类细胞表面蛋白，是细胞黏附分子的受体。整合素的一个子集识别其配体中的RGD基序，其结合既介导细胞-底物又介导细胞-细胞相互作用。RGD多肽和模拟物，除了提供对细胞黏附的基本机制的洞察外，还是治疗血栓形成和癌症等疾病的潜在治疗剂。
The tripeptide Arg-Gly-Asp (RGD) was originally identified as the sequence within fibronectin that mediates cell attachment. The RGD motif has now been found in numerous other proteins and supports cell adhesion in many, but not all, of these. The integrins, a family of cell-surface proteins, act as receptors for cell adhesion molecules. A subset of the integrins recognize the RGD motif within their ligands, the binding of which mediates both cell-substratum and cell-cell interactions. RGD peptides and mimetics, in addition to providing insights into the fundamental mechanisms of cell adhesion, are potential therapeutic agents for the treatment of diseases such as thrombosis and cancer.