Hypofractionated radiotherapy with carbon ion beams for prostate cancer
Hypofractionated radiotherapy with carbon ion beams for prostate cancer
复制标题
DOI：
10.1016/j.ijrobp.2005.04.022
复制
发表时间：
2005-11-15
影响因子：
7
通讯作者：
Tsujii, H
中科院分区：
文献类型：
--
作者：
Tsuji, H;Yanagi, T;Tsujii, H
目的：局部前列腺癌的低分割适形碳离子放射治疗的结果进行了分析，特别考虑到正常组织的发病率和生化无复发率（bNED）。方法和材料：进行分析，为201例患者治疗的剂量分割方案建立在1995年6月至2004年2月之间进行的三个临床试验。结果：没有3级或更高的毒性，观察到在直肠或泌尿生殖系统，2级直肠或泌尿生殖系统的发病率仅为1.0%和6.0%，分别为毒性，生存率，从局部复发的自由度，和bNED.Results。总的5年生化无复发生存率为83.2%，无任何局部复发。Gleason评分、初始PSA和T分期均为bNED的重要预后因素，Gleason评分的患者中bNED的预后率为97.1%
Purpose: Analysis of the results of hypofractionated conformal carbon ion radiotherapy for localized prostate cancer was performed, with special regard to normal tissue morbidity and biochemical relapse-free rate (bNED).Methods and Materials: Analysis was performed for 201 patients treated with the dose fractionation regimen established during three clinical trials performed between June 1995 and February 2004. Outcomes were measured in terms of toxicity, survival, freedom from local recurrence, and bNED.Results: No Grade 3 or higher toxicities were observed in either the rectum or genitourinary system, and the Incidences of Grade 2 rectum or genitourinary morbidity were only 1.0% and 6.0%, respectively. The overall 5-year biochemical relapse-free survival was 83.2% without any local recurrence. Gleason score, initial PSA, and T stage were all significant prognostic factors for bNED, which was 97.1% in patients with Gleason score