HEPATIC IRON CONCENTRATION AS A PREDICTOR OF RESPONSE TO INTERFERON-ALFA THERAPY IN CHRONIC HEPATITIS-C
HEPATIC IRON CONCENTRATION AS A PREDICTOR OF RESPONSE TO INTERFERON-ALFA THERAPY IN CHRONIC HEPATITIS-C
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DOI：
10.1016/0016-5085(95)90209-0
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发表时间：
1995-04-01
期刊：
影响因子：
29.4
通讯作者：
BACON, BR
中科院分区：
文献类型：
--
作者：
OLYNYK, JK;REDDY, KR;BACON, BR
背景/目标：有报道肝铁浓度（HIC）可能影响慢性病毒性肝炎患者对干扰素治疗的反应。本研究旨在探讨慢性丙型肝炎患者HIC与干扰素治疗反应的关系。方法：对三个中心治疗的58例慢性丙型肝炎患者的肝活检标本进行HIC测定。3例患者患有轻度慢性丙型肝炎，35例患有中度至重度慢性丙型肝炎，20例患有活动性肝硬化。在这58例患者中的51例中测定了血清铁蛋白水平。对治疗的反应定义为治疗结束时丙氨酸氨基转移酶水平的正常化。结果：24例患者（41%）对治疗有反应。HIC通常在正常范围内（1100 μ g/g），87%血清铁蛋白浓度升高的患者对干扰素α治疗无反应。结论：HIC似乎影响慢性丙型肝炎患者对干扰素α治疗的反应。已经确定了一个慢性丙型肝炎患者亚组，其中HIC>1100 μ g/g预测88%的患者无应答。
Background/Aims: It has been reported that hepatic iron concentration (HIC) may influence response to therapy in chronic viral hepatitis, The aim of this study was to determine the relationship between HIC and response to interferon alfa therapy in patients with chronic hepatitis C. Methods: HIC was measured in liver biopsy specimens from 58 patients with chronic hepatitis C treated at three centers. Three patients had mild chronic hepatitis C, 35 had moderate to severe chronic hepatitis C, and 20 had active cirrhosis. Serum ferritin levels were measured in 51 of these 58 patients. Response to therapy was defined as normalization of alanine aminotransferase levels at the end of treatment. Results:Twenty-four patients (41%) responded to therapy. HICs were generally within the normal range (1100 mu g/g and 87% of patients with an elevated serum ferritin concentration did not respond to interferon alfa therapy. Conclusions: HIC seems to influence response to interferon alfa therapy among patients with chronic hepatitis C. A subgroup of patients with chronic hepatitis C has been identified for which an HIC of >1100 mu g/g predicted nonresponse in 88% of patients.