Proton pump inhibitors as a risk factor for Clostridium difficile diarrhoea
Proton pump inhibitors as a risk factor for Clostridium difficile diarrhoea
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DOI：
10.1016/s0195-6701(03)00088-4
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发表时间：
2003-07-01
影响因子：
6.9
通讯作者：
Gaunt, N
中科院分区：
文献类型：
--
作者：
Cunningham, R;Dale, B;Gaunt, N
艰难梭菌是住院患者结肠炎的主要感染原因。发病率正在增加，并且与显著的死亡率、发病率和住院时间增加相关。主要危险因素是广谱抗生素的使用，抗生素限制是最有效的控制措施。我们进行了一项回顾性病例对照研究，以调查质子泵抑制剂（PPI）的使用是否是一个额外的风险因素。PPI使用前8周内与C的风险增加相关。艰难性腹泻（比值比2.5，95% CI 1.5-4.2）。减少不必要的PPI使用可能是减少这种感染发生率的另一种策略。(C)2003年，医院感染协会。由爱思唯尔科技有限公司出版。保留所有权利。
Clostridium difficile is the main infectious cause of colitis in hospital inpatients. The incidence is increasing, and it is associated with significant mortality, morbidity, and increased Length of stay. The main risk factor is use of broad-spectrum antibiotics, and antibiotic restriction is the most effective control measure. We carried out a retrospective case-control study to investigate whether use of proton pump inhibitors (PPI) was an additional risk factor. PPI use within the preceding eight weeks was associated with an increased risk of C. difficile diarrhoea (odds ratio 2.5, 95% CI 1.5-4.2). Reduction of unnecessary PPI use may be an additional strategy to reduce the incidence of this infection. (C) 2003 The Hospital Infection Society. Published by Elsevier Science Ltd. All rights reserved.