Duration of myocardial early systolic lengthening for diagnosis of coronary artery disease
Duration of myocardial early systolic lengthening for diagnosis of coronary artery disease
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DOI：
10.1136/openhrt-2018-000896
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发表时间：
2018-06-01
期刊：
影响因子：
2.7
通讯作者：
Kuwahara, Koichiro
中科院分区：
文献类型：
--
作者：
Minamisawa, Masatoshi;Koyama, Jun;Kuwahara, Koichiro
目的 冠状动脉疾病 (CAD) 患者的心肌早期收缩期延长 (ESL) 持续时间延长。然而，目前评价生理性心肌缺血的金标准——血流储备分数（FFR）与ESL之间的关系尚未被研究。本研究的目的是探讨左心室 (LV) ESL 持续时间是否可以识别 CAD 患者，并检查 FFR 与 LV ESL 持续时间之间的关系。 方法 在这项针对 75 名疑似或已知 CAD 患者的单中心、横断面、前瞻性研究中，我们在冠状动脉造影或经皮冠状动脉介入治疗前一天进行了静息时二维斑点追踪超声心动图。心尖 3 个视图用于检查 ESL 持续时间，定义为从 Q 波出现到最大心肌收缩期延长的时间。结果 35 名患者有非显着狭窄。 40 名 CAD 患者接受了 FFR 测试：17 名患者的 FFR >= 0.8，23 名患者的 FER= 0.8，FER 患者的时间为 39.6 +/- 29.5 毫秒
Objective Myocardial early systolic lengthening (ESL) duration is prolonged in patients with coronary artery disease (CAD). However, the relationship between the fractional flow reserve (FFR), the current gold standard for evaluating physiological myocardial ischaemia, and ESL has not been studied. The aims of this study were to investigate whether left ventricular (LV) ESL duration could identify patients with CAD, and to examine the relationship between FFR and LV ESL duration.Methods In this single-centre, cross-sectional, prospective study of 75 patients with suspected or known CAD, we performed two-dimensional speckle tracking echocardiography at rest on the day before coronary angiography or percutaneous coronary intervention. Apical 3 views were used to examine ESL duration, defined as time from onset of the Q wave to maximum myocardial systolic lengthening.Results Thirty-five patients had non-significant stenosis. Forty patients with CAD underwent FFR testing: 17 had an FFR >= 0.8 and 23 had an FER= 0.8 and 39.6 +/- 29.5 ms in patients with FER