Ultraflexible, large-area, physiological temperature sensors for multipoint measurements
Ultraflexible, large-area, physiological temperature sensors for multipoint measurements
复制标题
DOI：
10.1073/pnas.1515650112
复制
发表时间：
2015-11-24
影响因子：
11.1
通讯作者：
Someya, Takao
中科院分区：
文献类型：
--
作者：
Yokota, Tomoyuki;Inoue, Yusuke;Someya, Takao
我们报告了一种基于半结晶丙烯酸酯聚合物和石墨的复合材料的柔性和可印刷的热传感器的制造方法，其具有20 mK的高灵敏度和小于100 ms的高速响应时间。这些设备在生理条件下具有高重复性（1,800次），在接近体温时表现出大的电阻变化。器械性能在很大程度上不受弯曲至700 μ m以下半径的影响，这允许适形应用于活组织表面。传感温度可以在25摄氏度和50摄氏度之间调节，这涵盖了所有相关的生理温度。此外，我们展示了灵活的有源矩阵热传感器，可以解决空间温度梯度在一个大的区域。利用这种灵活的超灵敏温度传感器，我们成功地在体内测量了大鼠肺在呼吸过程中0.1摄氏度的周期性温度变化，而不受恒定组织运动的干扰。这一结果最终表明，尽管核心温度和吸入空气温度之间存在很大差异，但温血动物的肺仍保持令人惊讶的温度稳定性。
We report a fabrication method for flexible and printable thermal sensors based on composites of semicrystalline acrylate polymers and graphite with a high sensitivity of 20 mK and a high-speed response time of less than 100 ms. These devices exhibit large resistance changes near body temperature under physiological conditions with high repeatability (1,800 times). Device performance is largely unaffected by bending to radii below 700 mu m, which allows for conformal application to the surface of living tissue. The sensing temperature can be tuned between 25 degrees C and 50 degrees C, which covers all relevant physiological temperatures. Furthermore, we demonstrate flexible active-matrix thermal sensors which can resolve spatial temperature gradients over a large area. With this flexible ultrasensitive temperature sensor we succeeded in the in vivo measurement of cyclic temperatures changes of 0.1 degrees C in a rat lung during breathing, without interference from constant tissue motion. This result conclusively shows that the lung of a warm-blooded animal maintains surprising temperature stability despite the large difference between core temperature and inhaled air temperature.