Injection and Sexual Behavior Profiles among People Who Inject Drugs in Miami, Florida.
Injection and Sexual Behavior Profiles among People Who Inject Drugs in Miami, Florida.
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DOI：
10.1080/10826084.2022.2083171
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发表时间：
2022
影响因子：
2
通讯作者：
Bartholomew, Tyler S.
中科院分区：
文献类型：
--
作者：
Chueng, Teresa A.;Tookes, Hansel E.;McLaughlin, Megan;Arcaro-Vinas, Angela M.;Serota, David P.;Bartholomew, Tyler S.
注射吸毒的动态和高风险的性行为加剧了艾滋病毒和丙型肝炎病毒感染的风险。已发表的关于注射吸毒者（PWID）的文献研究了假设队列行为同质性的感染风险。根据注射和性风险对子群体进行分类，可以更公平地了解注射器服务规划（ssp）如何为每个类别调整减少伤害的资源。我们探讨了PWID的注射和性风险概况，以确定班级成员的重要预测因素。数据收集自迈阿密戴德县SSP的1272名参与者。潜在类分析（LCA）检查了10个注射/性行为指标如何聚集在一起以创建概况。模型拟合统计和多变量多项潜在类别回归确定了最佳类别结构和类别成员的显著预测因子。我们评估了SSP的访问量、纳洛酮的获取、HIV/HCV检测和流行率以及自我报告的伤口发生率。确定了三种不同的注射/性风险概况：低注射/高性风险（LIHS） （9.4%）；高度注射/中度性行为（HIMS） （18.9%）；低注射/低性（LILS）（71.7%）。报告同性恋/双性恋取向和注射甲基苯丙胺的参与者更有可能属于LIHS类别。LIHS班的HIV患病率较高，而HIMS班的丙型肝炎患病率较高。与LILS成员相比，HIMS成员更有可能经历不稳定的住房，同性恋/双性恋取向，海洛因或快速球注射，以及自我认同为女性。与LILS相比，HIMS队列成员有更多的SSP访问、纳洛酮使用和伤口发生率。了解PWID亚群可增强高危人群预防措施的重要性，重点干预措施包括抗逆转录病毒管理和LIHS类成员获得安全套，以及HCV筛查和伤口护理。
The dynamics of injection drug use and higher-risk sexual practices compound the risk of HIV and HCV acquisition. Published literature on people who inject drugs (PWID) has examined risk of infection assuming homogeneity of cohort behavior. Categorizing subgroups by injection and sexual risk can inform a more equitable approach to how syringe services programs (SSPs) adapt harm reduction resources to each class. We explored injection and sexual risk profiles among PWID to determine significant predictors of class membership. Data were collected from 1,272 participants at an SSP in Miami-Dade County. Latent Class Analysis (LCA) examined how 10 injection/sexual behavior indicators cluster together to create profiles. Model fit statistics and multivariable multinomial latent class regression identified the optimal class structure and significant predictors of class membership. We assessed SSP visits, naloxone access, HIV/HCV testing and prevalence, and incidence of self-reported wounds. Three distinct profiles of injection/sexual risk were determined: Low Injection/High Sexual (LIHS) (9.4%); High Injection/Moderate Sexual (HIMS) (18.9%); and Low Injection/Low Sexual (LILS) (71.7%). Participants reporting gay/bisexual orientation and methamphetamine injection more likely belonged to the LIHS class. LIHS class members had higher prevalence of HIV, while those of HIMS reported increased hepatitis C prevalence. Compared to members of LILS, those of HIMS more likely experienced unstable housing, gay/bisexual orientation, heroin or speedball injection, and identifying as women. HIMS cohort members had more SSP visits, naloxone accessed, and wound incidence than those of LILS. Understanding PWID subgroups amplifies the importance of PrEP for those engaging in highest risk behavior, with focused interventions of antiretroviral management and access to condoms for members of the LIHS class and HCV screening with wound care for those belonging to HIMS.
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影响因子：
4.5
作者：
Fernandes RM;Cary M;Duarte G;Jesus G;Alarcão J;Torre C;Costa S;Costa J;Carneiro AV
通讯作者：
Carneiro AV
影响因子：
2.5
作者：
Jacka, B.;Bray, B. C.;Grebely, J., Sr.
通讯作者：
Grebely, J., Sr.
影响因子：
33.9
作者：
Cranston, Kevin;Alpren, Charles;Demaria, Alfred, Jr.
通讯作者：
Demaria, Alfred, Jr.
影响因子：
168.9
作者：
Hurley, SF;Jolley, DJ;Kaldor, JM
通讯作者：
Kaldor, JM
影响因子：
4.4
作者：
Bartholomew, Tyler S.;Tookes, Hansel E.;Feaster, Daniel J.
通讯作者：
Feaster, Daniel J.