International Spread of an Epidemic Population of Salmonella enterica Serotype Kentucky ST198 Resistant to Ciprofloxacin
International Spread of an Epidemic Population of Salmonella enterica Serotype Kentucky ST198 Resistant to Ciprofloxacin
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DOI：
10.1093/infdis/jir409
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发表时间：
2011-09-01
影响因子：
6.4
通讯作者：
Weill, François-Xavier
中科院分区：
文献类型：
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作者：
Le Hello, Simon;Hendriksen, Rene S.;Weill, François-Xavier
法国、英格兰和威尔士、丹麦和美国的国家沙门氏菌监测系统发现，最近出现了对环丙沙星具有高度耐药性的肯塔基州肠道沙门氏菌血清型多重耐药分离株。2002年（3例）至2008年（174例）期间，共发现489例人间病例。这些分离株属于由多位点序列类型ST 198、XbaI脉冲场凝胶电泳簇X1和沙门氏菌基因组岛1变体SGI 1-K的存在所定义的单个克隆。这个克隆体可能是在20世纪90年代和21世纪初在埃及经过三个步骤选出的，现在已经传播到非洲的几个国家，最近又传播到中东。家禽已被确定为该克隆感染的潜在主要媒介。国家和国际当局应实施持续监测和适当的控制措施，以限制该菌株的传播。
National Salmonella surveillance systems from France, England and Wales, Denmark, and the United States identified the recent emergence of multidrug-resistant isolates of Salmonella enterica serotype Kentucky displaying high-level resistance to ciprofloxacin. A total of 489 human cases were identified during the period from 2002 (3 cases) to 2008 (174 cases). These isolates belonged to a single clone defined by the multilocus sequence type ST198, the XbaI-pulsed-field gel electrophoresis cluster X1, and the presence of the Salmonella genomic island 1 variant SGI1-K. This clone was probably selected in 3 steps in Egypt during the 1990s and the early 2000s and has now spread to several countries in Africa and, more recently, in the Middle East. Poultry has been identified as a potential major vehicle for infection by this clone. Continued surveillance and appropriate control measures should be implemented by national and international authorities to limit the spread of this strain.