Palladium-catalyzed aerobic oxidative dehydrogenation of cyclohexenes to substituted arene derivatives.
Palladium-catalyzed aerobic oxidative dehydrogenation of cyclohexenes to substituted arene derivatives.
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DOI：
10.1021/ja512770u
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发表时间：
2015-03-18
影响因子：
15
通讯作者：
Stahl SS
中科院分区：
文献类型：
--
作者：
Iosub AV;Stahl SS
钯（II）催化剂系统已被确定为取代的环己烯有氧脱氢相应的芳烃衍生物。使用蒽醌-2-磺酸钠（AMS）作为助催化剂提高了产物产率。在反应中容许广泛的官能团，并描述了该方法的范围和限制。环己烯的催化脱氢在基于邻苯二甲酰亚胺的TRPA 1活性调节剂的有效途径中展示。
A palladium(II) catalyst system has been identified for aerobic dehydrogenation of substituted cyclohexenes to the corresponding arene derivatives. Use of sodium anthraquinone-2-sulfonate (AMS) as a co-catalyst enhances the product yields. A wide range of functional groups are tolerated in the reactions, and the scope and limitations of the method are described. The catalytic dehydrogenation of cyclohexenes is showcased in an efficient route to a phthalimide-based TRPA1 activity modulator.