Changes in Serum Fatty Acid Levels During the First Year After Bariatric Surgery
Changes in Serum Fatty Acid Levels During the First Year After Bariatric Surgery
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DOI：
10.1007/s11695-015-1980-4
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发表时间：
2016-08-01
期刊：
影响因子：
2.9
通讯作者：
Kvalheim, Olav Martin
中科院分区：
文献类型：
--
作者：
Lin, Chenchen;Vage, Villy;Kvalheim, Olav Martin
我们评估了腹腔镜袖状胃切除术（LSG）和十二指肠转流术（BPDDS）对血清脂肪酸（FA）水平的影响。特别是，我们检查了手术对脂肪酸二十碳五烯酸（EPA）与花生四烯酸（AA）的比例的影响，心血管健康我们的假设是，LSG和BPDDS影响FA水平，但BPDDS可能有更持久的影响，因为BPDSS叠加肠吸收不良胃restriction.Serum样本禁食过夜后，收集手术前3个月和1天，3天，3个月，和12个月后，手术从10 BPDDS患者和23 LSG患者。通过气相色谱法定量16种脂肪酸的水平。采用Wilcoxon符号秩检验比较术前和术后EPA和AA的浓度以及EPA与AA的比值，使用假发现率进行多重检验校正，在校正多重检验的显著性水平后，BPDDS术后三个采样点的EPA/AA比值均低于术前两个采样点，p < 0.05。对于LSG，在术后3天和3个月时，该比值较低，p < 0.05，但在12个月后则不然。LSG和BPDDS均显著降低EPA/AA比值，并低于推荐值，但LSG患者在大约12个月后恢复至正常值，而BPDDS患者则不然。
We have assessed the effects of laparoscopic sleeve gastrectomy (LSG) and biliopancratic diversion with a duodenal switch (BPDDS) on fatty acid (FA) levels in serum. In particular, we examine the impact of surgery on the ratio of the FAs eicosapentaenoic acid (EPA) to arachidonic acid (AA) which impacts, e.g., cardiovascular health. Our hypothesis is that LSG and BPDDS influence the FA levels but that BPDDS may have a more persistent impact since BPDSS superimposes intestinal malabsorption on gastric restriction.Serum samples after overnight fasting were collected 3 months and 1 day before surgery and 3 days, 3 months, and 12 months after surgery from 10 BPDDS patients and 23 LSG patients. The levels of 16 FAs were quantified by gas chromatography. Preoperative and postoperative concentrations of EPA and AA and the ratio of EPA to AA were compared by Wilcoxon signed-rank test corrected for multiple testing using false discovery rate.The ratio of EPA/AA at each of the three postoperative sampling points was lower than at the two preoperative sampling points for BPDDS with p < 0.05 after correcting significance levels for multiple testing. For LSG, the ratio was lower with p < 0.05 at 3 days and at 3 months after surgery, but not after 12 months.Both LSG and BPDDS lower the ratio of EPA/AA significantly and below recommended values, but LSG patients resurge toward normal values after approximately 12 months, while BPDDS patients do not.