The neurophysiology of hydrogen sulfide.
The neurophysiology of hydrogen sulfide.
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DOI：
10.2174/187152811794776295
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发表时间：
2011-03
期刊：
影响因子：
--
通讯作者：
W. Rong;H. Kimura;D. Grundy
中科院分区：
文献类型：
--
作者：
W. Rong;H. Kimura;D. Grundy
硫化氢（H（2）S）是中枢和外周神经系统的第三大内源性气体介质。H（2）S由三种酶产生，即胱硫醚β-合酶（CBS）、胱硫醚γ-裂解酶（CSE）和3-巯基丙酮酸硫转移酶（3 MST）。在中枢神经系统中，H（2）S主要由星形胶质细胞中的CBS和神经元中的3 MST产生，参与认知、记忆、心肺功能调节和神经保护。在周围神经系统中，有证据表明H（2）S可能参与心肺和胃肠道功能的自主控制以及疼痛和炎症。
Hydrogen sulfide (H(2)S) has emerged as the third endogenous gaseous mediator in the central and peripheral nervous system. H(2)S is generated by three enzymes, cystathionine β-synthase (CBS), cystathionine γ-lyase (CSE) and 3-mercaptopyruvate sulfurtransferase (3MST). In the CNS, H(2)S, generated mainly by CBS in astrocytes and 3MST in neurons, appears to participate in cognition, memory, regulation of the cardiopulmonary functions and neuroprotection. In the peripheral nervous system, evidence suggests that H(2)S may be involved in autonomic control of the cardiopulmonary and gastrointestinal functions as well pain and inflammation.