RESPONSE OF LARYNGEAL AFFERENT-FIBERS TO MECHANICAL AND CHEMICAL STIMULI
RESPONSE OF LARYNGEAL AFFERENT-FIBERS TO MECHANICAL AND CHEMICAL STIMULI
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DOI：
10.1113/jphysiol.1974.sp010605
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发表时间：
1974-01-01
影响因子：
5.5
通讯作者：
WISE, JCM
中科院分区：
文献类型：
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作者：
BOUSHEY, HA;RICHARDSON, PS;WISE, JCM
1.我们记录了从麻醉猫的上级喉神经解剖的“单纤维”的传入活动。选择对喉上皮温和机械刺激有反应的单位进行研究。有髓纤维的受体根据其自发活动进行分组。第1组纤维几乎没有或没有自发活动;第2组纤维具有恒定和连续的自发活动。第1组纤维有广泛的适应率。它们的传导速度在3.0 ~ 30米/秒之间。受体一般刺激氨和蒸馏水，并经常由CS防暴剂，5和10%CO2，200 ppm SO2，和香烟烟雾。组胺、苯基二胍、石墨粉、100 ppm二氧化硫和生理盐水滴一般不刺激神经元。第2组纤维适应缓慢。其传导速度在8.0和26.5 m/sec之间。氨通常，蒸馏水有时，兴奋这些纤维，而5和10%的CO2混合物抑制它们。少数2组纤维的pH敏感，抑制酸和碱性缓冲液的刺激。香烟烟雾具有复杂的作用，要么是兴奋，要么是抑制，或者在不同的时间，两者兼而有之。组胺，P.d.g.，CS、SO_2、盐水滴和粉尘对上述指标无影响。记录来自一根无髓鞘纤维（传导速度1.9 m/sec），该纤维对用线敲击上皮和组胺有反应，P.d.g.和氨蒸汽施加到上皮。我们考虑的网站，方法的兴奋和反射行动的不同受体的描述。
1. We have recorded afferent activity from ‘single fibres’ dissected from the superior laryngeal nerve of anaesthetized cats.2. Units which responded to gentle mechanical stimulation of the larynx epithelium were chosen for study.3. Receptors with myelinated fibres were grouped according to their spontaneous activity. Group 1 fibres had little or no spontaneous activity: group 2 fibres had constant and continuous spontaneous activity.4. Group 1 fibres had a wide range of adaptation rates. Their conduction velocities lay between 3·0 and 30 m/sec. The receptors were generally stimulated by ammonia and distilled water and often by CS riot control agent, 5 and 10% CO2, 200 ppm SO2, and cigarette smoke. Histamine, phenyl diguanide, graphite dust, 100 ppm SO2and saline drops did not generally excite the fibres.5. Group 2 fibres were slowly adapting. Their conduction velocities ranged between 8·0 and 26·5 m/sec. Ammonia usually, and distilled water sometimes, excited these fibres while 5 and 10% CO2mixtures inhibited them. A minority of group 2 fibres were pH sensitive, inhibited by acids and stimulated by alkaline buffers. Cigarette smoke had complex actions, either excitation, inhibition or, at different times, both. Histamine, P.d.g., CS, SO2, saline drops and dust had no action on these fibres.6. Recordings were made from one unmyelinated fibre (conduction velocity 1·9 m/sec) which responded to stroking of the epithelium with a thread and to histamine, P.d.g. and ammonia vapour applied to the epithelium.7. We consider the site, method of excitation and reflex actions of the different receptors described.