Long-term potentiation of neuron-glia synapses mediated by Ca2+-permeable AMPA receptors
Long-term potentiation of neuron-glia synapses mediated by Ca2+-permeable AMPA receptors
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DOI：
10.1126/science.1124669
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发表时间：
2006-06-09
期刊：
影响因子：
56.9
通讯作者：
Duan, Shumin
中科院分区：
文献类型：
--
作者：
Ge, Woo-Ping;Yang, Xiu-Juan;Duan, Shumin
脑中神经元和神经胶质细胞之间的相互作用可能在神经回路的发育、维持和可塑性中发挥重要作用。在海马神经元和NG 2细胞之间已经发现了快速神经元-胶质突触传递，NG 2细胞是广泛分布于脑中的大胶质样细胞的独特群体。我们报告说，这些神经元-胶质细胞突触经历类似于兴奋性突触的长时程增强（LTP）的活性依赖性修饰，这是神经元可塑性的标志。然而，与许多神经元-神经元突触LTP的诱导不同，神经元-NG 2突触LTP的诱导和表达均涉及NG 2细胞上的Ca 2+可渗透AMPA受体。
Interactions between neurons and glial cells in the brain may serve important functions in the development, maintenance, and plasticity of neural circuits. Fast neuron-glia synaptic transmission has been found between hippocampal neurons and NG2 cells, a distinct population of macroglia-like cells widely distributed in the brain. We report that these neuron-glia synapses undergo activity-dependent modifications analogous to long-term potentiation (LTP) at excitatory synapses, a hallmark of neuronal plasticity. However, unlike the induction of LTP at many neuron-neuron synapses, both induction and expression of LTP at neuron-NG2 synapses involve Ca2+-permeable AMPA receptors on NG2 cells.