Injectable polymer/nanomaterial composites for the fabrication of three-dimensional biomaterial scaffolds
Injectable polymer/nanomaterial composites for the fabrication of three-dimensional biomaterial scaffolds
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DOI：
10.1088/1748-605x/ab82ea
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发表时间：
2020-07-01
影响因子：
4
通讯作者：
Kehr, Nermin S.
中科院分区：
文献类型：
--
作者：
Motealleh, Andisheh;Dorri, Pooya;Kehr, Nermin S.
目前的组织工程技术集中于创建可用于微创手术和受控局部药物递送应用的可注射系统。迄今为止开发的材料基于天然和合成聚合物及其纳米复合材料，但其中许多材料无法同时提供机械稳定性，拉伸性和增强的细胞粘附性。在这种情况下，为了产生同时具有几种性质的先进的可注射纳米复合聚合物，我们使用了纳米材料以及用生物活性分子化学官能化的纳米材料。我们的3D打印聚合物/纳米材料复合材料（纳米复合聚合物）显示出增强的机械性能，良好的形状保真度，无毒，可拉伸性，生物稳定性和细胞增殖性。
Current tissue engineering techniques have been intensively focused on creating injectable systems that can be used in minimally invasive surgery and controlled local drug delivery applications. The materials developed so far are based on natural and synthetic polymers and their nanocomposites, but many of them fail to simultaneously provide mechanical stability, stretchability and enhanced cell adhesiveness. In this context, to generate advanced injectable nanocomposite polymers that concurrently possess several properties, we used nanomaterials as well as nanomaterials that are chemically functionalized with bioactive molecules. Our 3D-printed polymer/nanomaterial composites (nanocomposite polymers) displayed enhanced mechanical properties, good shape fidelity, non-toxicity, stretchability, biostability and cell adhesiveness.