Disruption of the alternative pathway convertase occurs at the staphylococcal surface via the acquisition of factor H by Staphylococcus aureus.
Disruption of the alternative pathway convertase occurs at the staphylococcal surface via the acquisition of factor H by Staphylococcus aureus.
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通过金黄色葡萄球菌获取 H 因子，在葡萄球菌表面发生旁路转化酶的破坏。
DOI：
10.1016/j.molimm.2010.11.014
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发表时间：
2011
影响因子：
3.6
通讯作者：
Cunnion,KenjiM
中科院分区：
文献类型：
--
作者：
Sharp,JuliaA;Cunnion,KenjiM
Staphylococcus aureus is a significant human pathogen that causes skin-structure, invasive, and hospital-associated infections worldwide. The complement system is vital to innate defense against many bacterial infections. As shown with other pathogens, mechanisms for circumventing complement attack may include recruitment of the complement regulatory protein factor H (fH). In the present study, we show that S. aureus binds fH in a dose-dependent and time-dependent manner. Interestingly, this interaction does not require complement activation nor C3-fragment presence and occurs efficiently in the absence of other serum components suggesting a mechanism other than bridging between intermediary molecules. However, fH binding is greater when incubated with normal human serum compared to heat-inactivated serum, which suggests that complement activation may enhance fH binding. S. aureus-bound fH was found to inhibit the alternative pathway through disruption of the alternative pathway C3 convertase as shown by an increase in Bb release and a decrease in total C3-fragment deposition. Furthermore, S. aureus-bound fH retains cofactor activity for factor-I mediated cleavage of C3b. These studies show that the acquisition of fH to the S. aureus surface inhibits complement-mediated opsonization via disruption of the alternative pathway convertase; thus, we report an immune-evasion mechanism not previously described for S. aureus.
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补体受体 1 和 2（CD35 和 CD21）、C3、C4 和 C5 在金黄色葡萄球菌菌血症小鼠存活中的作用。
DOI：
--
发表时间：
2004
期刊：
Journal of Laboratory and Clinical Medicine
影响因子：
--
作者：
K. Cunnion;D. Benjamin;C. Hester;M. Frank
通讯作者：
M. Frank
影响因子：
3.9
作者：
Zipfel, PF;Skerka, C;Remuzzi, G
通讯作者：
Remuzzi, G
影响因子：
4.8
作者：
Jongerius, Ilse;Garcia, Brandon L.;Rooijakkers, Suzan H. M.
通讯作者：
Rooijakkers, Suzan H. M.
鉴定人补体成分 C3 的 727–767 片段内的残基，该残基对其与因子 H 和补体受体 1（CR1、CD35）的相互作用非常重要*
影响因子：
4.8
作者：
A. Oran;D. Isenman
通讯作者：
D. Isenman
DOI：
--
发表时间：
1985
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Horstmann,RD;Pangburn,MK;Müller-Eberhard,HJ
通讯作者：
Müller-Eberhard,HJ