Deletion of Sulfonylurea Receptor 2 in the Adult Myocardium Enhances Cardiac Glucose Uptake and Is Cardioprotective
Deletion of Sulfonylurea Receptor 2 in the Adult Myocardium Enhances Cardiac Glucose Uptake and Is Cardioprotective
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DOI：
10.1016/j.jacbts.2018.11.012
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发表时间：
2019-04-01
影响因子：
9.7
通讯作者：
McNally, Elizabeth M.
中科院分区：
文献类型：
--
作者：
Aubert, Gregory;Barefield, David Y.;McNally, Elizabeth M.
成人心肌依赖氧化代谢。在缺血性心肌中，例如胚胎心脏，糖酵解作为燃料来源的贡献更为显着。磺酰脲受体 2 (SUR2) 先前被认为与适应产后生活过程中发生的正常心肌从糖酵解代谢到氧化代谢的转变有关。现在，该受体在成年小鼠心肌中被选择性删除，从而防止缺血再灌注损伤。 SUR2 缺失的心肌细胞葡萄糖摄取增强，并且 SUR2 与主要葡萄糖转运蛋白形成复合物。这些数据将 SUR2 受体确定为改变心脏代谢以防止心肌损伤的靶标。 (C) 2019 年作者。由爱思唯尔代表美国心脏病学会基金会出版。
The adult myocardium relies on oxidative metabolism. In ischemic myocardium, such as the embryonic heart, glycolysis contributes more prominently as a fuel source. The sulfonylurea receptor 2 (SUR2) was previously implicated in the normal myocardial transition from glycolytic to oxidative metabolism that occurs during adaptation to postnatal life. This receptor was now selectively deleted in adult mouse myocardium resulting in protection from ischemia reperfusion injury. SUR2-deleted cardiomyocytes had enhanced glucose uptake, and SUR2 forms a complex with the major glucose transporter. These data identify the SUR2 receptor as a target to shift cardiac metabolism to protect against myocardial injury. (C) 2019 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation.