Transcytosis of nanoparticle and dendrimer delivery systems: evolving vistas
Transcytosis of nanoparticle and dendrimer delivery systems: evolving vistas
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DOI：
10.1016/s0169-409x(01)00184-3
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发表时间：
2001-10-01
影响因子：
16.1
通讯作者：
Hussain, N
中科院分区：
文献类型：
--
作者：
Florence, AT;Hussain, N
颗粒物质在胃肠道中的易位现在是一种有充分文献记载的现象，为通过生物可降解纳米颗粒封装的药物提供了新的潜力，这些药物具有较差的溶解谱和不稳定的化学成分。最近几年，描述这种方法的不同方面和该领域的多学科性质的出版物数量有所增加。这篇综述描述了来自这一相当零散的领域和同源领域的数据，以提供一个物理化学的观点，说明口服药物传递载体的表面化学的重要性，以及它们在摄取之前与肠道内容物的相互作用。研究了淋巴组织和非淋巴组织的作用，并讨论了生物粘附的作用。在纳米技术应用于口服途径的背景下，讨论了通过树状大分子和星形支链分子对药物进行分子包封的令人兴奋的潜力。发展前景包括更好地理解肠上皮的可塑性和m细胞诱导，以及疾病状态对颗粒摄取的影响。在这篇综述中，我们讨论了一些被认为对理解这一主题至关重要的问题，包括(i)颗粒摄取的一些背景知识（几篇综述的主题），（ii）影响摄取的因素，如直径和表面电荷和特征，（iii）肠道中颗粒相互作用的动态性质，（iv）捕获、粘附、摄取、胞吞和易位过程的动态性质，以及(v)表面配体的影响。(C) 2001 Elsevier Science B.V.版权所有
The translocation of particulate matter across the gastrointestinal tract is now a well documented phenomenon offering new potential for the delivery of drugs with poor dissolution profiles and labile chemistries via encapsulation in biodegradable nanoparticles. The last few years have seen an acceleration in the number of publications describing the varying facets of this approach and the multidisciplinary nature of this field. This review delineates data from this rather fragmented area and from cognate fields to provide a physicochemical viewpoint of the importance of surface chemistries of oral drug delivery vehicles and their interactions in and with gut contents prior to uptake. The role of lymphoid and non-lymphoid tissues is examined, and the role of bioadhesion is discussed. The exciting potential of molecular encapsulation of drugs via dendrimers and star branched molecules is discussed in the context of nanotechnological applications for the oral route. Evolving vistas include a better understanding of the plasticity of the intestinal epithelium and M-cell induction as well as the influence of disease states on particulate uptake. In this review we address a number of issues deemed vital to an understanding of the subject including (i) some background knowledge on particulate uptake (the subject of several reviews), (ii) factors affecting uptake such as diameter and surface charge and character, (iii) the dynamic nature of particle interactions in the gut, (iv) the dynamic nature of the processes of capture, adhesion, uptake, transcytosis and translocation, and (v) the influence of surface ligands. (C) 2001 Elsevier Science B.V. All rights reserved.