Non-Destructive and Non-Invasive Assessment of Mechanical Properties in Heart Valve Tissue Engineering
Non-Destructive and Non-Invasive Assessment of Mechanical Properties in Heart Valve Tissue Engineering
复制标题
心脏瓣膜组织工程机械性能的非破坏性和非侵入性评估
DOI：
10.1115/sbc2008-192799
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发表时间：
2008
期刊：
影响因子：
--
通讯作者：
F. Baaijens
中科院分区：
文献类型：
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作者：
J. Kortsmit;N. Driessen;M. Rutten;F. Baaijens
尽管最近取得了进展，但与天然主动脉瓣相比，组织工程心脏瓣膜的机械性能仍然缺乏机械强度[1]。尽管已知生物反应器系统中的循环组织应变可促进组织形成[2]，但具体的最佳加载方案尚未确定。为了更好地了解机械负荷对组织发育的影响，在培养过程中应该监测和控制组织结构的力学行为。然而，目前使用的机械表征方法(如拉伸试验、压痕试验)是破坏性的，因此只能在组织培养的末期进行。以前提出了一种实验-数值方法，用于实时和非侵入性地评估在生物反应器系统中培养过程中的小叶变形[3]。这种方法的进一步发展现在能够对工程心脏瓣膜的机械性能进行非侵入性和非破坏性的评估。版权所有©2008，ASME
Despite recent progress, mechanical properties of tissue engineered heart valves still lack mechanical strength compared to native aortic valves [1]. Although cyclic tissue straining in bioreactor systems is known to enhance tissue formation [2], specific optimal loading protocols have not yet been defined. To get a better insight in the effects of mechanical loading on tissue development, mechanical behavior of tissue constructs should be monitored and controlled during culture. However, currently used methods for mechanical characterization (e.g. tensile tests, indentation tests) are destructive and can therefore only be performed at the end stage of tissue culture. An experimental-numerical approach was previously proposed by which leaflet deformation was assessed during culture in a bioreactor system, real-time and non-invasively [3]. Further development of this approach now enables a non-invasive and non-destructive assessment of mechanical properties of engineered heart valve leaflets.Copyright © 2008 by ASME