Genetic characterization of H7N2 influenza virus isolated from pigs
Genetic characterization of H7N2 influenza virus isolated from pigs
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DOI：
10.1016/j.vetmic.2011.06.011
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发表时间：
2011-12-15
影响因子：
3.3
通讯作者：
Lyoo, Young S.
中科院分区：
文献类型：
--
作者：
Kwon, Tae Yong;Lee, Sung Seok;Lyoo, Young S.
由于猪的呼吸道上皮同时表达α2-3和α2-6连接的唾液酸作为甲型流感病毒的受体，因此它们被认为是通过基因重配产生大流行性流感病毒的混合容器。从屠宰场收集的猪肺中分离出 H7N2 流感病毒（A/swine/KU/16/2001）。对流感病毒的所有八个基因进行了测序，系统发育分析表明，A/swine/KU/16/2001起源于香港，禽H7N2和H5N3流感病毒之间发生了基因重配。首次在猪体内分离出 H7 流感病毒，为具有大流行潜力的流感病毒的基因重组提供了机会，并强调了监测非典型猪流感病毒的重要性。 (C) 2011 Elsevier B.V. 保留所有权利。
Because pigs have respiratory epitheliums which express both alpha 2-3 and alpha 2-6 linked sialic acid as receptors to influenza A viruses, they are regarded as mixing vessel for the generation of pandemic influenza viruses through genetic reassortment. A H7N2 influenza virus (A/swine/KU/16/2001) was isolated from pig lungs collected from the slaughterhouse. All eight genes of the influenza virus were sequenced and phylogenetic analysis indicated that A/swine/KU/16/2001 originated in Hong Kong and genetic reassortment had occurred between the avian H7N2 and H5N3 influenza viruses. The first isolation of H7 influenza virus in pigs provides the opportunity for genetic reassortment of influenza viruses with pandemic potential and emphasizes the importance of surveillance for atypical swine influenza viruses. (C) 2011 Elsevier B.V. All rights reserved.