Protective Effects of Kaempferol (3,4′,5,7-tetrahydroxyflavone) against Amyloid Beta Peptide (Aβ)-Induced Neurotoxicity in ICR Mice
Protective Effects of Kaempferol (3,4′,5,7-tetrahydroxyflavone) against Amyloid Beta Peptide (Aβ)-Induced Neurotoxicity in ICR Mice
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DOI：
10.1271/bbb.90585
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发表时间：
2010-02-01
影响因子：
1.6
通讯作者：
Shin, Dong-Hoon
中科院分区：
文献类型：
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作者：
Kim, Jae Kyeom;Choi, Soo Jung;Shin, Dong-Hoon
为了确定山奈酚的作用，使用大鼠嗜铬细胞瘤细胞 (PC12) 和癌症研究所 (ICR) 小鼠作为神经元模型。使用体外测定，山奈酚对 PC12 细胞中氧化应激诱导的细胞毒性具有保护作用。服用山奈酚还可以显着逆转淀粉样蛋白 β 肽 (Aβ) 引起的 Y 迷宫测试中的表现受损。总而言之，本文报告的结果表明，有必要进一步研究山奈酚对阿尔茨海默病相关途径的影响。
To determine the effects of kaempferol, rat pheochromocytoma cells (PC12) and Institute of Cancer Research (ICR) mice were utilized as neuronal models. Using in vitro assays, kaempferol was shown to have protective effects against oxidative stress-induced cytotoxicity in PC12 cells. Administration of kaempferol also significantly reversed amyloid beta peptide (A beta)-induced impaired performance in a Y-maze test. Taken altogether, the results reported here suggest that further investigation is warranted of the influence of kaempferol on pathways related to Alzheimer's disease.