Comparison of Respiratory Resistance Measurements Made with an Airflow Perturbation Device with Those from Impulse Oscillometry.
Comparison of Respiratory Resistance Measurements Made with an Airflow Perturbation Device with Those from Impulse Oscillometry.
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DOI：
10.1155/2013/165782
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Vossoughi J
中科院分区：
文献类型：
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作者：
Pan J;Saltos A;Smith D;Johnson A;Vossoughi J
气流扰动装置（APD）是一种便携式、易于使用和快速响应的仪器，用于测量人体呼吸阻力。然而，APD的数据有限，无法根据已建立的技术对其进行验证。本研究使用机械系统来模拟人类呼吸的正常范围，以使用临床上接受的脉冲多普勒（IOS）技术来验证APD。验证系统由一个正弦流发生器组成，该发生器具有10个标准化阻力配置，这些配置显示代表0.12 - 0.95 kPa·L−1 ·s（1.2-9.7 cm H2O·L−1 ·s）的总阻力范围。在0.15 L·s-1的恒定气流下记录并比较机械系统的脉冲流速测量和APD测量。IOS和APD测量在评估标称电阻方面都是准确的。此外，APD测量值与IOS测量值之间存在较强的线性关系（R2 = 0.999）。第二个系列的测量是在10名志愿者的呼吸流动路径中添加外部电阻器。一旦用机械系统校准，APD给出的呼吸阻力测量值在IOS测量值的5%范围内。由于其与IOS测量的可比性，APD测量被证明是呼吸阻力的有效代表。
The airflow perturbation device (APD) has been developed as a portable, easy to use, and a rapid response instrument for measuring respiratory resistance in humans. However, the APD has limited data validating it against the established techniques. This study used a mechanical system to simulate the normal range of human breathing to validate the APD with the clinically accepted impulse oscillometry (IOS) technique. The validation system consisted of a sinusoidal flow generator with ten standardized resistance configurations that were shown to represent a total range of resistances from 0.12 to 0.95 kPa·L−1 ·s (1.2–9.7 cm H2O·L−1 ·s). Impulse oscillometry measurements and APD measurements of the mechanical system were recorded and compared at a constant airflow of 0.15 L·s−1. Both the IOS and APD measurments were accurate in assessing nominal resistance. In addition, a strong linear relationship was observed between APD measurements and IOS measurements (R 2 = 0.999). A second series of measurements was made on ten human volunteers with external resistors added in their respiratory flow paths. Once calibrated with the mechanical system, the APD gave respiratory resistance measurements within 5% of IOS measurements. Because of their comparability to IOS measurements, APD measurements are shown to be valid representations of respiratory resistance.