REGIONAL DIFFERENCES IN THICKNESS (CELL LAYERS) OF HUMAN STRATUM-CORNEUM - ULTRASTRUCTURAL ANALYSIS
REGIONAL DIFFERENCES IN THICKNESS (CELL LAYERS) OF HUMAN STRATUM-CORNEUM - ULTRASTRUCTURAL ANALYSIS
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DOI：
10.1111/1523-1747.ep12701670
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发表时间：
1974-01-01
影响因子：
6.5
通讯作者：
ODLAND, GF
中科院分区：
文献类型：
--
作者：
HOLBROOK, KA;ODLAND, GF
角质层作为皮肤穿透的限速屏障的重要性已经在文献中得到了很好的证明。也有数据表明，该区域的屏障功能因身体不同部位而异。然而，对于已知的影响渗透率的两个形态参数--厚度和细胞层数的区域变化却很少受到关注。在本研究中，在六名成年志愿者的身体的四个选定的样本区域以及按性别和年龄分开的两个更均匀的亚组中，细胞层的平均厚度和平均细胞层数都有显著的地区差异。而来自总人口的汇集数据和来自男性和女性亚组的汇集数据大体一致。已经表明，在一个区域内也有明显的个体变异，这是每个个体特有的和特有的。细胞层的数量似乎解释了厚度的变化。
The importance of the stratum corneum as the rate-limiting barrier to perceutaneous penetration has been well documented in the literature. Data have also been reported which suggest that the barrier function of this zone varies among different regions of the body. However, little attention has been given to regional variation of two morphologic parameters know to affect permeability–thickness and number of cell layers. In the present study, significant regional variation in both the mean thickness and the mean number of cell layers has been documented for four selected , sample regions of the body of a population of six adult volunteers, and for two more homogeneous subgroups separated by sex and age. While the pooled data from the total population and the pooled data from the male and female subgroups are in general agreement. It has been shown that there is also marked individual variation within a region that is characteristic and specific for each individual. The number of cell layers appears to account for the variation in thickness.