Effect of nerve activity on transport of nerve growth factor and dopamine β-hydroxylase antibodies in sympathetic neurones
Effect of nerve activity on transport of nerve growth factor and dopamine β-hydroxylase antibodies in sympathetic neurones
复制标题
神经活动对交感神经元神经生长因子和多巴胺β-羟化酶抗体转运的影响
DOI：
10.1016/0006-8993(81)90452-2
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发表时间：
1981
期刊：
影响因子：
2.9
通讯作者：
R. Rush
中科院分区：
文献类型：
--
作者：
G. Lees;I. Chubb;C. Freeman;L. Geffen;R. Rush
通过在豚鼠前房内注射125i标记的神经生长因子（NGF）和抗多巴胺β-羟化酶（DBH）抗体，研究神经活动对神经生长因子（NGF）和多巴胺β-羟化酶（DBH）抗体摄取和逆行转运的影响。同侧颈上神经节（SCG）去中心化对NGF或抗dbh逆行转运均无显著影响。Phenoxybenzamine可使抗dbh增加50%，但不会增加NGF的积累，这种影响可通过事先去中心化来阻止。这表明NGF的摄取独立于突触囊泡成分的获取。
The effect of nerve activity on the uptake and retrograde transport of nerve growth factor (NGF) and dopamine β-hydroxylase (DBH) antibodies was studied by injecting125I-labelled NGF and anti-DBH into the anterior eye chamber of guinea-pigs. Decentralization of the ipsilateral superior cervical ganglion (SCG) had no significant effect on the retrograde transport of either NGF or anti-DBH. Phenoxybenzamine produced a 50% increase in anti-DBH but not NGF accumulation and this effect was prevented by prior decentralization. This demonstrates that NGF is taken up independently of the retrieval of synaptic vesicle components.