Respiratory adenovirus infections in immunocompetent and immunocompromised adult patients
Respiratory adenovirus infections in immunocompetent and immunocompromised adult patients
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DOI：
10.1017/s0950268819002176
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发表时间：
2019-01-01
影响因子：
4.2
通讯作者：
Pahlman, L., I
中科院分区：
文献类型：
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作者：
Cederwall, S.;Pahlman, L., I
腺病毒(ADV)可引起儿童和免疫功能低下患者的严重呼吸道感染，但对具有免疫能力的成年人的严重ADV肺炎知之甚少。在这项回顾性研究中，我们比较了免疫功能低下和免疫功能正常的成人患者的呼吸道感染和ADV引起的肺炎的临床表现和感染严重程度。结果表明，ADV可导致免疫功能正常和免疫功能低下的患者发生严重感染，两组患者的临床表现和住院、机械通气和抗病毒治疗的需求相同。未发现健康人严重ADV感染的潜在危险因素。
Adenovirus (AdV) can cause severe respiratory infections in children and immunocompromised patients, but less is known about severe AdV pneumonia in immunocompetent adults. In this retrospective study, we compared respiratory tract infections and pneumonia caused by AdV in immunocompromised and immunocompetent adult patients regarding clinical presentation and severity of infection. The results show that AdV can cause severe infections in both immunocompetent and immunocompromised patients, and the clinical presentation and need for hospitalisation, mechanical ventilation and antiviral treatment were equal in both groups. No underlying risk factors for severe AdV infection in healthy individuals were identified.