In vitro Activity of Combination Therapy with Cefepime, Piperacillin-Tazobactam, or Meropenem with Ciprofloxacin against Multidrug-Resistant Pseudomonas aeruginosa Strains
In vitro Activity of Combination Therapy with Cefepime, Piperacillin-Tazobactam, or Meropenem with Ciprofloxacin against Multidrug-Resistant Pseudomonas aeruginosa Strains
复制标题
头孢吡肟、哌拉西林-他唑巴坦或美罗培南与环丙沙星联合治疗多重耐药铜绿假单胞菌菌株的体外活性
作者：
I. Erdem;Metin Kucukercan;N. Ceran
多重耐药铜绿假单胞菌的流行逐年增加，在临床实践中已交替提供各种抗菌药物组合的治疗。本研究的目的是通过时间杀灭法评价美罗培南、头孢吡肟或哌拉西林-他唑巴坦与环丙沙星联合用药对多重耐药铜绿假单胞菌菌株的体外作用。结果表明，两种β-内酰胺类药物与环丙沙星和三种β-内酰胺类药物与环丙沙星的组合对5株多重耐药铜绿假单胞菌中的4株无体外作用。一种β内酰胺（美罗培南、头孢吡肟、哌拉西林-他唑巴坦）与环丙沙星的组合对一种多药耐药铜绿假单胞菌菌株具有协同作用，该菌株对环丙沙星敏感，对美罗培南、头孢吡肟和哌拉西林-他唑巴坦具有耐药性。没有一种组合对这些多药耐药菌株具有拮抗作用。
The prevalence of multidrug-resistant Pseudomonas aeruginosa strains has been increasing every year, and treatment with various antimicrobial combinations has been offered alternatively in the clinical practice. The aim of this study was to evaluate the in vitro effects of combinations of meropenem, cefepime, or piperacillin-tazobactam with ciprofloxacin against multidrug-resistant P. aeruginosa strains by the time-kill method. The results show that both the combination of two beta lactams with ciprofloxacin and three beta lactams with ciprofloxacin against 4 of 5 multidrug-resistant P. aeruginosa strains has no effect in vitro. The combination of one beta lactam (meropenem, cefepime, piperacillin-tazobactam) with ciprofloxacin has a synergistic effect against one strain of multidrug-resistant P. aeruginosa that is ciprofloxacin susceptible and resistant to meropenem, cefepime, and piperacillin-tazobactam. None of the combinations had an antagonistic effect against these multidrug-resistant strains.