A symptom provocation study of posttraumatic stress disorder using positron emission tomography and script-driven imagery.
A symptom provocation study of posttraumatic stress disorder using positron emission tomography and script-driven imagery.
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DOI：
10.1001/archpsyc.1996.01830050014003
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发表时间：
1996-05
影响因子：
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通讯作者：
S. Rauch;B. Kolk;R. Fisler;N. Alpert;S. Orr;C. Savage;Fischman Aj;M. Jenike;R. Pitman
中科院分区：
文献类型：
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作者：
S. Rauch;B. Kolk;R. Fisler;N. Alpert;S. Orr;C. Savage;Fischman Aj;M. Jenike;R. Pitman
背景以前的研究已经使用症状激发和正电子发射断层扫描来描绘介导各种焦虑状态的大脑系统。使用类似的方法，本研究的目的是测量与创伤后应激障碍（PTSD）症状相关的局部脑血流变化。方法8例PTSD患者，筛选为生理反应脚本驱动的意象症状激发范式，依次暴露于听力创伤和中性脚本结合正电子发射断层扫描。心率和情绪状态的主观措施，获得了每一个条件。统计绘图技术被用来确定显着的大脑激活的位置。结果与对照组相比，创伤组右侧边缘、颞叶边缘和视觉区的标准化血流量增加;左下额叶和颞叶中部皮质的标准化血流量减少。结论：研究结果表明，与PTSD症状状态相关的情绪是由右半球的边缘系统和脑边缘系统介导的。视觉皮层的激活可能对应于PTSD再体验现象的视觉成分。
BACKGROUND Previous studies have used symptom provocation and positron emission tomography to delineate the brain systems that mediate various anxiety states. Using an analogous approach, the goal of this study was to measure regional cerebral blood flow changes associated with posttraumatic stress disorder (PTSD) symptoms. METHODS Eight patients with PTSD, screened as physiologically responsive to a script-driven imagery symptom provocation paradigm, were exposed sequentially to audiotaped traumatic and neutral scripts in conjunction with positron emission tomography. Heart rate and subjective measures of emotional state were obtained for each condition. Statistical mapping techniques were used to determine locations of significant brain activation. RESULTS Increases in normalized blood flow were found for the traumatic as compared with control conditions in right-sided limbic, paralimbic, and visual areas; decreases were found in left inferior frontal and middle temporal cortex. CONCLUSIONS The results suggest that emotions associated with the PTSD symptomatic state are mediated by the limbic and paralimbic systems within the right hemisphere. Activation of visual cortex may correspond to the visual component of PTSD reexperiencing phenomena.