Transport of steroid hormones

Transport of steroid hormones
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类固醇激素的运输

DOI:
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发表时间:
1976
期刊:
影响因子:
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通讯作者:
A. Vermeulen
A. Vermeulen
中科院分区:
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文献类型:
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作者:
A. Vermeulen

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1913年,Oppenheimer 1观察到,当将血清加入药物溶液中时,心脏葡糖苷对分离的青蛙心脏的毒性较小。他解释说,这一现象是由于血清中的胶体成分吸附洋地黄类固醇所致。这可能是第一个表明类固醇-蛋白质相互作用的研究。
In 1913 Oppenheimer1 observed that cardiac glucosides are less toxic to the isolated frog heart when serum is added to the drug solution. This phenomenon he explained by adsorption of the digitalis steroids by the colloidal components of the serum. This was probably the first study indicating a steroid—protein interaction.