Nitric oxide-producing polyurethanes
Nitric oxide-producing polyurethanes
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DOI：
10.1021/bm049419y
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发表时间：
2005-03-01
影响因子：
6.2
通讯作者：
West, JL
中科院分区：
文献类型：
--
作者：
Jun, HW;Taite, LJ;West, JL
血栓形成和最终的内膜增生是小直径合成血管移植失败的主要原因。为了解决这些问题，我们将二醇二氮烯修饰的产生一氧化氮 (NO) 的肽掺入聚氨酯中，以提高这种生物相容性聚合物的抗血栓性。聚氨酯薄膜在生理条件下大约2个月不会产生NO，并且该材料的机械性能适合血管移植应用。与对照聚氨酯相比，血小板对释放 NO 的聚氨酯的粘附显着降低。此外，在释放NO的聚氨酯存在下，内皮细胞的生长受到刺激，而平滑肌细胞的生长则受到极大的抑制。这种生物活性材料能够抑制血小板粘附和平滑肌细胞增殖，同时促进内皮化，这表明这种产生NO的聚氨酯可能适合作为小直径血管移植物的候选材料。
Thrombus formation and eventual intimal hyperplasia are the leading causes of small-diameter synthetic vascular graft failure. To combat these issues, we have incorporated a diazeniumdiolate- modified nitric oxide (NO)-producing peptide into a polyurethane to improve the thromboresistance of this biocompatible polymer. NO production by polyurethane films occurred for approximately 2 months under physiological conditions, and mechanical properties of the material were suitable for vascular graft applications. Platelet adhesion to NO-releasing polyurethane was dramatically decreased compared to control polyurethane. Furthermore, endothelial cell growth was stimulated in the presence of the NO-releasing polyurethane, while smooth muscle cell growth was greatly inhibited. The ability of this bioactive material to inhibit platelet adhesion and smooth muscle cell proliferation while encouraging endothelialization suggests that this NO-generating polyurethane may be suitable as a candidate material for small-diameter vascular grafts.