α-MsO/TsO/Cl ketones as oxidized alkyne equivalents: redox-neutral rhodium(III)-catalyzed C-H activation for the synthesis of N-heterocycles.
α-MsO/TsO/Cl ketones as oxidized alkyne equivalents: redox-neutral rhodium(III)-catalyzed C-H activation for the synthesis of N-heterocycles.
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DOI：
10.1002/anie.201310272
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发表时间：
2014-03
影响因子：
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通讯作者：
Da‐Gang Yu;Francisco de Azambuja;F. Glorius
中科院分区：
文献类型：
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作者：
Da‐Gang Yu;Francisco de Azambuja;F. Glorius
α-卤代酮和拟卤代酮首次在过渡金属催化的C-H活化中用作C（sp（3））基亲电试剂，并在Rh（III）催化的氧化还原中性成环反应中用作氧化炔等价物，以生成各种N-杂环。这种转换是高效和可扩展的。由于反应条件温和，可以耐受多种官能团。
α-Halo and pseudohalo ketones are used for the first time as C(sp(3))-based electrophiles in transition-metal-catalyzed C-H activation and as oxidized alkyne equivalents in Rh(III)-catalyzed redox-neutral annulations to generate diverse N-heterocycles. This transformation is efficient and scalable. Due to the mild reaction conditions, a variety of functional groups could be tolerated.