Nontuberculous Mycobacterial Lung Infections in Ontario, Canada: Clinical and Microbiological Characteristics
Nontuberculous Mycobacterial Lung Infections in Ontario, Canada: Clinical and Microbiological Characteristics
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DOI：
10.1007/s00408-010-9241-8
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发表时间：
2010-08-01
期刊：
影响因子：
5
通讯作者：
Jamieson, Frances
中科院分区：
文献类型：
--
作者：
Marras, Theodore K.;Mehta, Mauli;Jamieson, Frances
研究目的本研究的目的是确定肺部非结核分枝杆菌 (NTM) 感染的性别和临床表型频率以及 NTM 分离株的疾病频率。设计该研究是两个重叠队列的回顾性观察队列研究：人群队列和临床队列。设置 这项研究是在加拿大安大略省多伦多的大学健康网络和安大略分枝杆菌学实验室进行的。患者或参与者 人群队列由 2003 年安大略省所有患有一种或多种肺部 NTM 分离株的患者组成。临床队列由 2002-2003 年在我们医院患有一种或多种肺部 NTM 分离株的所有患者组成。干预措施 该研究需要审查实验室记录和人口统计数据（两个队列）以及详细的临床记录（临床队列）。测量和结果 在人群队列 (N = 1651) 中，女性总体占 48%，符合微生物疾病标准的女性占 51%。在临床队列 (N = 552) 中，女性总体占 48%，其中 55% 患有 NTM 疾病。在人群队列中，45% 的患者符合微生物疾病标准，在临床队列中，46% 的患者患有疾病。 MAC 分离株患者中 51% 的人群队列病例符合微生物学疾病标准，52% 的临床队列病例符合所有疾病标准。女性更常见地满足人口队列中的微生物疾病标准（51% vs. 45%，P = 0.02）和临床队列中的所有疾病标准（53% vs. 40%，P = 0.03）。在临床队列患者中，26%（13 名女性，44 名男性）患有纤维空洞，62%（101 名女性，37 名男性）患有结节性支气管扩张。结论 患有疾病的女性占少数。结节性支气管扩张在女性中最常见，但每种放射学类型中每种性别的比例都很高。 NTM 分离，特别是 MAC，经常与疾病相关。
Study Objectives The aim of this study was to determine gender and clinical phenotype frequencies in pulmonary nontuberculous mycobacterial (NTM) infection and the frequency of disease in NTM isolates. Design The study is a retrospective observational cohort study of two overlapping cohorts: population cohort and clinical cohort. Setting The study was conducted at the University Health Network and Ontario Mycobacteriology Laboratory in Toronto, Ontario, Canada. Patients or Participants The population cohort consisted of all patients with one or more pulmonary NTM isolates in Ontario in 2003. The clinical cohort consisted of all patients with one or more pulmonary NTM isolates at our hospital in 2002-2003. Interventions The study entailed the review of laboratory records and demographics (both cohorts) and detailed clinical records (clinical cohort). Measurements and Results In the population cohort (N = 1651), females comprised 48% overall and 51% with microbiological disease criteria. In the clinical cohort (N = 552), females comprised 48% overall and 55% with NTM disease. In the population cohort, 45% fulfilled microbiological disease criteria, and in the clinical cohort 46% of patients had disease. Patients with MAC isolates fulfilled microbiological disease criteria in 51% of population cohort cases and all disease criteria in 52% of clinical cohort cases. Women more commonly fulfilled microbiological disease criteria in the population cohort (51 vs. 45%, P = 0.02) and all disease criteria in the clinical cohort (53 vs. 40%, P = 0.03). Among clinical cohort patients, 26% (13 women, 44 men) had fibrocavitation, while 62% (101 women, 37 men) had nodular bronchiectasis. Conclusions Women comprised a small majority with disease. Nodular bronchiectasis in women was most common, but significant proportions of each gender with each radiographic type were observed. NTM isolation, particularly MAC, was frequently associated with disease.