Immunoregulation in aging.
Immunoregulation in aging.
复制标题
衰老过程中的免疫调节。
DOI：
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发表时间：
1987
期刊：
影响因子：
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通讯作者：
L. Bonomo
中科院分区：
文献类型：
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作者：
S. Antonaci;E. Jirillo;L. Bonomo
免疫系统的衰老导致淋巴细胞功能能力的下降。在这方面，已经提供了减少T和B细胞介导的应答的证据。T-B调节也受到衰老过程的影响。由于淋巴细胞的比例与在年轻供体中观察到的相似，因此细胞内或细胞外因素可能在受损的免疫应答中起重要作用。事实上已经假定T或B细胞的内在缺陷。然而，可溶性抑制因子或LK产生减少似乎代表了免疫应答下降中涉及的关键事件。然而，在过去的几年中，重点已经放在老年人淋巴细胞膜微粘度增加[Rivnay et al：Mech Ageing Dev 10：71-79，1979]。总之，这些发现表明了一种多因素的治疗方法，用于纠正老年人受损的免疫反应。
Senescence of the immune system leads to a decline of functional capacities of lymphoid cells. In this regard, evidence has been provided for a reduction of T and B cell-mediated responses. T-B regulation is also affected by the aging process. Since the proportion of lymphocytes is similar to that observed in young donors, either intracellular or extracellular factors may play an important role in the impaired immunoresponsiveness. An intrinsic defect of T or B cells has been in fact postulated. However, soluble suppressive factors or decreased LK production seem to represent the key events involved in the decline of the immune response. Nevertheless, over the past few years emphasis has been given to the increased lymphocyte membrane microviscosity in the elderly [Rivnay et al: Mech Ageing Dev 10: 71-79, 1979]. All together, these findings suggest a multifactorial therapeutic approach for the correction of the impaired immune response in aged individuals.