An association of human T-cell lymphotropic virus type I infection with vascular dementia
An association of human T-cell lymphotropic virus type I infection with vascular dementia
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DOI：
10.1111/j.1600-0404.1997.tb00288.x
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发表时间：
1997-11-01
影响因子：
3.5
通讯作者：
Yamasaki, K
中科院分区：
文献类型：
--
作者：
Kira, J;Hamada, T;Yamasaki, K
为探讨HTLV-Ⅰ感染与痴呆的关系，对50 ~ 89岁的老年痴呆患者进行了抗HTLV-Ⅰ gag 100-130抗体的ELISA检测和头颅CT检查。痴呆组抗HTLV-Ⅰ抗体阳性率（24/130，18.5%）显著高于非痴呆组（11/139，7.9%）（P=0.0169）。在各种类型的痴呆中，发现HTLV-Ⅰ血清阳性与血管性痴呆显著相关（11/48，23%）（P=0.0087），但与阿尔茨海默型痴呆无关。此外，HTLV-Ⅰ阳性还与巴宾斯基征、脑梗死严重程度、脑室扩张和CT显示的脑室周围透亮区有关。因此，HTLV-I的存在似乎是HTLV-I流行地区血管性痴呆的危险因素之一。
Subjects ranging in age from 50 to 89 years old, either with or without dementia were studied by both ELISA for anti-human T-cell lymphotropic virus type I (HTLV-I) gag 100-130 antibody and by cranial CT in order to clarify the relationship between HTLV-I infection and dementia. The frequency of anti-HTLV-I antibody was found to be significantly higher in the patients with dementia (24/130, 18.5%) than in those without dementia (11/139, 7.9%) (P=0.0169). Among the various types of dementia, HTLV-I seropositivity was found to be significantly associated with vascular dementia (11/48, 23%) (P=0.0087), but not with Alzheimer type dementia. In addition, HTLV-I seropositivity was also associated with Babinski sign, and the severity of cerebral infarction, ventricular dilatation and periventricular lucency on CT. The presence of HTLV-I therefore appears to be one of the risk factors for vascular dementia in HTLV-I endemic areas.