Four new steroid saponins with highly oxidized side chains from the leaves of Vernonia amygdalina
Four new steroid saponins with highly oxidized side chains from the leaves of Vernonia amygdalina
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DOI：
10.1016/j.phytol.2015.11.002
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发表时间：
2016-03-01
影响因子：
1.7
通讯作者：
Kong, Ling-Yi
中科院分区：
文献类型：
--
作者：
Quasie, Olga;Zhang, Yang-Mei;Kong, Ling-Yi
Vernoamyosides A - D（1 - 4）是从非洲药用植物扁桃斑鸠菊（菊科）的干叶中分离出的四种新的Δ(7, 9(11))豆甾烷型甾体皂苷。它们的结构通过光谱分析（高分辨电喷雾质谱、一维/二维核磁共振）和化学方法相结合的方式确定。这四种新化合物具有高度氧化的侧链（C - 20 - C - 29），并且在2 - 4中形成复杂的环系。测试了这些新化合物对脂多糖激活的RAW264.7巨噬细胞中一氧化氮产生的抑制作用。（C）2015欧洲植物化学学会。由爱思唯尔出版集团出版。保留所有权利。
Vernoamyosides A-D (1-4), four new Delta(7, 9(11)) stigmastane-type steroid saponins were isolated from the dried leaves of an African medicinal plant Vernonia amygdalina Delile (Asteraceae). Their structures were determined by a combination of spectroscopic analyses (HR-ESI-MS, 1D/2D NMR) and by chemical methods. These four new compounds possessed highly oxidized side chains (C-20-C-29), and formed complex ring systems in 2-4. The inhibitory effects on NO production in lipopolysaccharide-activated RAW264.7 macrophages of these new compounds were tested. (C) 2015 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.