FKBP5 : A Key Mediator of How Vertebrates Flexibly Cope with Adversity
FKBP5 : A Key Mediator of How Vertebrates Flexibly Cope with Adversity
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FKBP5：脊椎动物如何灵活应对逆境的关键调解者
DOI：
10.1093/biosci/biaa114
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发表时间：
2020
期刊：
影响因子：
10.1
通讯作者：
Martin, Lynn B
中科院分区：
文献类型：
--
作者：
Zimmer, Cedric;Hanson, Haley E;Wildman, Derek E;Uddin, Monica;Martin, Lynn B
下丘脑-垂体-肾上腺(HPA)轴调节的灵活性是应激恢复能力的重要中介，因为它帮助生物体适应、避免或补偿不断变化的环境中的急性和慢性挑战。糖皮质激素仍然是从医学到保护生物学的最受欢迎的指标，试图量化应激韧性，尽管人们对它们与个人健康、福利和健身的一致性持怀疑态度。我们认为，与热休克蛋白相关并参与糖皮质激素受体活性的辅伴侣分子FKBP5可能介导HPA的灵活性，从而影响应激韧性，因为它影响个体调节糖皮质激素的方式，从而使他们能够适当地调整表型以适应普遍的不利条件。尽管FKBP5分子在生物医学文献中得到了很好的研究，但对野生脊椎动物的FKBP5研究有限。在这篇文章中，我们强调了FKBP5在人类和实验啮齿动物中作为HPA轴灵活性的媒介在应对逆境中的潜在主要作用。
Flexibility in the regulation of the hypothalamic–pituitary–adrenal (HPA) axis is an important mediator of stress resilience as it helps organisms adjust to, avoid, or compensate for acute and chronic challenges across changing environmental contexts. Glucocorticoids remain the favorite metric from medicine to conservation biology to attempt to quantify stress resilience despite the skepticism around their consistency in relation to individual health, welfare, and fitness. We suggest that a cochaperone molecule related to heat shock proteins and involved in glucocorticoid receptor activity, FKBP5, may mediate HPA flexibility and therefore stress resilience because it affects how individuals can regulate glucocorticoids and therefore capacitates their abilities to adjust phenotypes appropriately to prevailing, adverse conditions. Although the molecule is well studied in the biomedical literature, FKBP5 research in wild vertebrates is limited. In the present article, we highlight the potential major role of FKBP5 as mediator of HPA axis flexibility in response to adversity in humans and lab rodents.