On the Function of Pentameric Phospholamban: Ion Channel or Storage Form?
On the Function of Pentameric Phospholamban: Ion Channel or Storage Form?
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DOI：
10.1016/j.bpj.2009.03.013
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发表时间：
2009-05-20
影响因子：
3.4
通讯作者：
Veglia, Gianluigi
中科院分区：
文献类型：
--
作者：
Becucci, Lucia;Cembran, Alessandro;Veglia, Gianluigi
Phospholamban (PLN) is an integral membrane protein that inhibits the sarcoplasmic reticulum Ca2+-ATPase, thereby regulating muscle contractility. We report a combined electrochemical and theoretical study demonstrating that the pentameric PLN does not possess channel activity for conducting chloride or calcium ions across the lipid membrane. This suggests that the pentameric configuration of PLN primarily serves as a storage form for the regulatory function of muscle relaxation by the PLN monomer.
