Hyperpolarization-activated current I(h) in nucleus of solitary tract neurons: regional difference in serotonergic modulation.
Hyperpolarization-activated current I(h) in nucleus of solitary tract neurons: regional difference in serotonergic modulation.
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DOI：
10.1254/jjp.88.459
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发表时间：
2002-04
期刊：
影响因子：
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通讯作者：
Yuki Iwahori;Y. Ikegaya;N. Matsuki
中科院分区：
文献类型：
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作者：
Yuki Iwahori;Y. Ikegaya;N. Matsuki
孤束核（NTS）包含负责基本生命功能的各种神经回路。我们研究了5-羟色胺（5-HT）对从NTS尾部、内侧和喙部急性分离的神经元超极化激活电流（I（h））的影响。与吻侧神经元相比，尾侧和内侧NTS神经元显示出较大的I（h）幅度。在这些神经元中，5-HT灌流以浓度依赖性方式增强Ih振幅。5-HT 1A受体拮抗剂NAN-190可阻断5-HT的作用。因此，5-HT 1A受体可能调节尾侧和内侧NTS神经元的I（h）通道活性。
The nucleus of solitary tract (NTS) contains diverse neural circuits responsible for basic vital functions. We examined the effect of serotonin (5-HT) on hyperpolarization-activated current (I(h)) in neurons acutely isolated from caudal, medial and rostral parts of the NTS. Caudal and medial NTS neurons showed a large amplitude of I(h) compared with rostral neurons. In these neurons, perfusion with 5-HT potentiated Ih amplitude in a concentration-dependent manner. The effect of 5-HT was blocked by NAN-190, a 5-HT1A receptor antagonist. Thus, 5-HT1A receptors may regulate I(h) channel activity in caudal and medial NTS neurons.