Distribution and localization of NMDA receptor subunit 1 in the visual cortex of strabismic and anisometropic amblyopic cats
Distribution and localization of NMDA receptor subunit 1 in the visual cortex of strabismic and anisometropic amblyopic cats
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DOI：
10.1097/00001756-199611250-00040
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发表时间：
1996-11
期刊：
影响因子：
1.7
通讯作者：
Z. Yin;S. Crewther;Mo Yang;D. Crewther
中科院分区：
文献类型：
--
作者：
Z. Yin;S. Crewther;Mo Yang;D. Crewther
最近有人提出，NMDA（N-甲基-D-天冬氨酸）受体的激活是诱导出生后早期发育过程中视觉皮层神经元的经验依赖性修饰的先决条件。一种针对 NMDA 受体亚基 1 (NMDA-R1) 的新型单克隆抗体已用于定位和比较正常猫和因单眼光学模糊或单眼内斜视引起的弱视而长大的猫的初级视觉皮层中受体的分布。尽管所有三组都在 II-III 层中显示出最密集的标记，但对皮质表面以下任何深度的免疫阳性细胞进行比较显示，斜视和屈光参差猫的频率明显低于正常猫，但屈光参差猫的频率高于斜视动物。在这两种弱视猫模型中，NMDA-R1 受体的表达与已知存在的兴奋性、双眼视力或神经元敏锐度水平之间似乎没有直接关系，因此提出了关于 NMDA 受体在视觉皮层可塑性过程中作用的确切性质的进一步问题。
ACTIVATION of NMDA (N-methyl-D-aspartate) receptors has recently been proposed as a prerequisite for the induction of experience-dependent modification of visual cortical neurones seen during early postnatal development. A new monoclonal antibody to the NMDA receptor subunit 1 (NMDA-R1) has been used to localize and compare the distribution of the receptors in the primary visual cortex of normal cats and those raised with either amblyopia induced by monocular optical blur or monocular esotropic strabismus. Although all three groups showed densest labelling in layers II-III, a comparison of immunopositive cells at any depth below the cortical surface showed a significantly lower frequency in strabismic and anisometropic cats than in normal cats, but a greater frequency in anisometropic cats that in strabismic animals. There appears to be no direct relationship between the expression of NMDA-R1 receptors and the level of excitability, binocularity or neuronal acuity known to exist in either of these two cat models of amblyopia, thus raising further questions as to the precise nature of the role of NMDA receptors in the processes of visual cortical plasticity.