CHROMOSOMAL LOCALIZATION OF 7 MEMBERS OF THE MURINE TGF-BETA SUPERFAMILY SUGGESTS CLOSE LINKAGE TO SEVERAL MORPHOGENETIC MUTANT LOCI
CHROMOSOMAL LOCALIZATION OF 7 MEMBERS OF THE MURINE TGF-BETA SUPERFAMILY SUGGESTS CLOSE LINKAGE TO SEVERAL MORPHOGENETIC MUTANT LOCI
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DOI：
10.1016/0888-7543(90)90480-i
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发表时间：
1990-03-01
期刊：
影响因子：
4.4
通讯作者：
JENKINS, NA
中科院分区：
文献类型：
--
作者：
DICKINSON, ME;KOBRIN, MS;JENKINS, NA
染色体位置已经被分配给了转化生长因子-β的七个成员。使用种间鼠回交的超家族。TGFb-1、-2和-3、BMP-2a和-3以及VGR-1基因的探针只能识别单个基因座，而BMP-2b探针只能识别两个独立分离的基因座(命名为BMP-2b1和BMP-2b2)。结果显示，这七个成员的转化生长因子-β。超家族定位于8条不同的染色体，表明转化生长因子-β。在进化过程中，家庭变得广泛分散。8个基因座中的5个(TGFb-1、BMP-2a、BMP-2b1、BMP-2b2、VGR-1)位于与结缔组织和骨骼疾病相关的突变基因座附近，这增加了至少一些突变是由转化生长因子-β相关基因缺陷引起的可能性。
Chromosomal locations have been assigned to seven members of the TGF-.beta. superfamily using an interspecific mouse backcross. Probes for the Tgfb-1, -2, and -3, Bmp-2a and -3, and Vgr-1 genes recognized only single loci, whereas the Bmp-2b probe recognized two independently segregating loci (designated Bmp-2b1 and Bmp-2b2). The results show that the seven members of the TGF-.beta. superfamily map to eight different chromosomes, indicating that the TGF-.beta. family has become widely dispersed during evolution. Five of the eight loci (Tgfb-1, Bmp-2a, Bmp-2b1, Bmp-2b2, Vgr-1) mapped near mutant loci associated with connective tissue and skeletal disorders, raising the possibility that at least some of these mutations results from defects in TGF-.beta.-related genes.