Clinical and commercial translation of advanced polymeric nanoparticle systems: opportunities and material challenges
Clinical and commercial translation of advanced polymeric nanoparticle systems: opportunities and material challenges
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DOI：
10.1088/2053-1613/aa5468
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发表时间：
2017-03-01
期刊：
影响因子：
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通讯作者：
Mitragotri, Samir
中科院分区：
文献类型：
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作者：
Anselmo, Aaron C.;Prabhakarpandian, Balabhaskar;Mitragotri, Samir
纳米颗粒递送系统在其临床应用中获得牵引力，并且被研究用于递送化疗药物、siRNA和其他试剂，以及作为诊断和成像应用。随着研究的重点是改善纳米颗粒的递送进展，很明显，纳米颗粒的物理化学性质在其生物学性能中起着重要作用。各种尺寸、形状、弹性和表面化学性质的纳米颗粒正变得越来越广泛;然而，从材料的角度来看，这提出了许多平移挑战。具体而言，随着纳米颗粒递送系统变得更加先进，其合成，放大和表征的方法需要随之而来。此外，由于技术的进步允许精确控制所有纳米颗粒参数，系统分析这些参数对纳米颗粒性能的影响的方法是必不可少的。在这里，我们广泛强调与纳米颗粒翻译相关的材料挑战，特别强调合成，放大，表征和生物性能分析。
Nanoparticle delivery systems are gaining traction in their clinical utility and are investigated for the delivery of chemotherapeutic drugs, siRNAs and other agents, and also as diagnostic and imaging applications. As research focused on improving the delivery of nanoparticles progresses, it is clear that the physicochemical properties of nanoparticles play an important role in their biological performance. Nanoparticles of various sizes, shapes, elasticities, and surface chemistries are becoming more widely used; however, this presents a number of translational challenges from a materials point of view. Specifically, as nanoparticle delivery systems become more advanced, methods for their synthesis, scale-up, and characterization need to follow suit. Furthermore, as advancements in technology allow for precise control over all nanoparticle parameters, approaches to systematically analyze the effects these parameters have on nanoparticle performance are essential. Here, we broadly highlight the material challenges associated with nanoparticle translation with specific emphasis on synthesis, scale-up, characterization, and analysis of biological performance.