Isolation and Characterization of Enterocin W, a Novel Two-Peptide Lantibiotic Produced by Enterococcus faecalis NKR-4-1
Isolation and Characterization of Enterocin W, a Novel Two-Peptide Lantibiotic Produced by Enterococcus faecalis NKR-4-1
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DOI：
10.1128/aem.06497-11
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发表时间：
2012-02-01
影响因子：
4.4
通讯作者：
Sonomoto, Kenji
中科院分区：
文献类型：
--
作者：
Sawa, Naruhiko;Wilaipun, Pongtep;Sonomoto, Kenji
粪肠球菌NKR-4-1分离自大肠杆菌，产生一种新的双肽羊毛硫抗生素，称为肠菌素W，包括W α和W β。肠菌素W的结构与植物菌素W相似。这两种肽协同作用，它们与细胞膜结合的顺序对它们的抑制活性很重要。
Enterococcus faecalis NKR-4-1 isolated from pla-ra produces a novel two-peptide lantibiotic, termed enterocin W, comprising W alpha and W beta. The structure of enterocin W exhibited similarity with that of plantaricin W. The two peptides acted synergistically, and their order of binding to the cell membrane was important for their inhibitory activity.