RNA silencing in plants
RNA silencing in plants
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DOI：
10.1038/nature02874
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发表时间：
2004-09-16
期刊：
影响因子：
64.8
通讯作者：
Baulcombe, D
中科院分区：
文献类型：
--
作者：
Baulcombe, D
在植物中至少有三种RNA沉默途径用于沉默特定的基因。在这些通路中，沉默信号可以被放大并在细胞之间传递，甚至可以通过反馈机制进行自我调节。这些途径的生物学作用已被确定，包括防御病毒，调节基因表达和染色质凝聚成异染色质。我们现在处于一个很好的位置，以调查基因组控制的遗传和表观遗传机制的这种功能多样性的全部范围。
There are at least three RNA silencing pathways for silencing specific genes in plants. In these pathways, silencing signals can be amplified and transmitted between cells, and may even be self-regulated by feedback mechanisms. Diverse biological roles of these pathways have been established, including defence against viruses, regulation of gene expression and the condensation of chromatin into heterochromatin. We are now in a good position to investigate the full extent of this functional diversity in genetic and epigenetic mechanisms of genome control.