Inverse coupling between ultradian oscillations in delta wave activity and heart rate variability during sleep
Inverse coupling between ultradian oscillations in delta wave activity and heart rate variability during sleep
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DOI：
10.1016/s1388-2457(01)00507-7
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发表时间：
2001-06-01
影响因子：
4.7
通讯作者：
Simon, C
中科院分区：
文献类型：
--
作者：
Brandenberger, G;Ehrhart, J;Simon, C
目的：探讨睡眠时心率变异性变化与脑电活动的关系。方法：研究对象为9例有规律非快眼运动-快眼运动(NREM-REM)睡眠周期的男性受试者。他们在一个实验夜晚进行了脑电和心脏记录。心率变异性由R-R间期频谱分析计算的低频/低频加高频功率之比[LF/(LF+HF)]在5分钟内确定。结果：低频/(LF+HF)比值在80-120min之间存在超常的节律，快速眼动(REM)睡眠时高水平，慢波睡眠(SWS)低水平。在睡眠阶段2，从REM睡眠到SWS的转换逐渐减少，而从SWS到REM睡眠的转换突然增加。这些振荡明显地与反映睡眠加深和闪电的夜间三角洲波活动的振荡相关联。心脏变化先于脑电变化约5分钟。结论：这些发现表明，在增量波活动和心率变异性的振荡之间存在反向耦合。它们表明了睡眠阶段2的不一致性，这是极端睡眠规则的基础。(C)2001爱思唯尔爱尔兰科学有限公司。保留所有权利。
Objective: We investigate the relationship between changes in heart rate variability and electroencephalographic (EEG) activity during sleep.Method: Nine male subjects with regular non-rapid-eye movement-rapid-eye movement (NREM-REM) sleep cycles were included in the study. They underwent EEG and cardiac recordings during one experimental night. Heart rate variability was determined over 5-min periods by the ratio of low frequency to low frequency plus high frequency power [LF/(LF + HF)] calculated using spectral analysis of R-R intervals. EEG spectra were analyzed using a fast Fourier transform algorithm.Results: We found an ultradian 80-120 min rhythm in the LF/(LF + HF) ratio, with high levels during rapid eye movement (REM) sleep and low levels during slow wave sleep (SWS). During sleep stage 2 there was a progressive decrease in the transition from REM sleep to SWS, and an abrupt increase from SWS to REM sleep. These oscillations were significantly coupled in a 'mirror-image' to the overnight oscillations in delta wave activity, which reflect sleep deepening and lightening. Cardiac changes preceded EEG changes by about 5 min.Conclusions: These findings demonstrate the existence of an inverse coupling between oscillations in delta wave activity and heart rate variability. They indicate a non-uniformity in sleep stage 2 that underlies ultradian sleep regulation. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.