Stabilization of telomeric G-quadruplex by ligand binding increases susceptibility to S1 nuclease
Stabilization of telomeric G-quadruplex by ligand binding increases susceptibility to S1 nuclease
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DOI：
10.1039/d1cc03294a
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发表时间：
2021-07-08
影响因子：
4.9
通讯作者：
Tera, Masayuki
中科院分区：
文献类型：
--
作者：
Ishikawa, Ryo;Yasuda, Mizuho;Tera, Masayuki
端粒G-四链体（G4）的热力学稳定的程度由G4配体L2 H2 - 6 OTD，一种端粒酶抑制素类似物的异构体，是负相关的敏感性S1核酸酶。L2 H2 - 6 OTD通过G4中的碱基翻转促进S1核酸酶活性，而不像G4配体在配体相互作用时抑制蛋白质与DNA/RNA结合的常规作用。
The extent of thermodynamic stabilization of telomeric G-quadruplex (G4) by isomers of G4 ligand L2H2-6OTD, a telomestatin analog, is inversely correlated with susceptibility to S1 nuclease. L2H2-6OTD facilitated the S1 nuclease activities through the base flipping in G4, unlike the conventional role of G4 ligands which inhibit the protein binding to DNA/RNA upon ligand interactions.